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IBL/Pregnenolone ELISA/DB52031/

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Kitsize12x8MethodELISAIncubationtime1x1h,1x10minStandardrange0.1-25ng/mLSpecimen/Volumes50µLserumSubstrate/isotopeTMB450nmRegulatoryStatus:EU:CEDetailsfor: PregnenoloneELISAEnzymeimmunoassayforthedirectquantitativedeterminationofPregnenoloneinhumanserum.Pregnenolone(3ß-hydroxypregn-5-en-20-one)isthefirststeroidtobederivedfromcholesterolinthepathwayofsteroidogenesis,anditisthecommonprecursorforalloftheadrenalandgonadalsteroids.ItsproductionoccursinthemitochondrionbycleavageoftheC-20sidechainofcholesterolbytheP-450SCCenzyme.Onceproduced,pregnenolonemaybeutilizedbytwopathwaysofsteroidogenesis.Pregnenolonemayeitherbeconvertedto17-OHpregnenoloneviatheenzymaticactionof17a-hydroxylaseortoprogesteroneviatheenzymaticactionof3ß-hydroxysteroiddehydrogenase.Elevatedpregnenolonelevelsoccurinformsofcongenitaladrenalhyperplasia(CAH),dueto3ß-hydroxysteroiddehydrogenasedeficiencyor17a-hydroxylasedeficiencies.Higherlevelshavealsobeenreportedinwomenwithidiopathichirsutism.Studiesonpregnenolonelevelsinregardtosexandagedifferencesindicatethatmaximumlevelsoccuratapproximately17and16yearsofageforwomenandmen,whileminimumlevelsoccuratapproximately37and38yearsofageforwomenandmen,respectively.Ingeneral,womenwerefoundtohaveslightlyhighervalueswhencomparedtomen.Manyareasofpregnenolonephysiologyremaintobeinvestigated.Currentresearchindicatesthatthedeterminationofpregnenoloneinserummaybeusefulforstudyingitsmetabolite,pregnenolonesulfate,whichhasbeenreportedtohavevariouseffectsinthemammalianbrainandcentralnervoussystem.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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