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IBL/Testosterone Luminescence Immunoassay/RE62031/

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RE62031

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Kitsize12x8MethodLuminescenceImmunoassayIncubationtime1x4h,1x10minStandardrange6.4-760pg/mLSpecimen/Volumes50µLsaliva/withoutextractionSubstrate/isotopeAcridiumbasedRegulatoryStatus:EU:CE,CDN:IVDDetailsfor: TestosteroneLuminescenceImmunoassayLuminescenceImmunoassayforthequantitativedeterminationoffreetestosteroneinsalivaandoftotaltestosteroneindilutedserum.Measurementoftestosterone(amalesexhormone)isusedinthediagnosisandtreatmentofdisordersinvolvingthemalesexhormones(androgens),includingprimaryandsecondaryhypogonADIsm,impotenceinmalesandinfemaleshirsutism(excessivehair)andvirilization(masculinization)duetotumors,polycysticovariesandadrenogenitalsyndromes.Testosterone,aC19-Steroid,isthemosteffectivenaturalhormoneinthefamilyofandrogens.Inmales,itismainlyproducedintheLeydigcellsofthetestes,onlyasmallamountisproducedintheadrenalcortex.Onthewhole,adultmaleshave10to20foldhighertestosteroneplasmaconcentrationsthanfemales.Inthecirculation,themainpartoftestosteroneisboundtoplasmaproteinslikesexhormonebindingglobuline(SHBG)andalbumine.Only1–2%ofthetestosteroneisunboundandthereforeBIOLOGicallyactive.Thefreetestosteroneisreleasedviathesalivaryglands.Intheircellsagreatpartofthehormoneistransformedto5a-Dihydrotestosterone.Nevertheless,theconcentrationoftestosteroneinsalivareflectstheleveloffreetestosteroneinplasma.Testosteronelevelsinfemalesshouldbemeasuredinpatientshavingclinicalsymptomsofvirilismcausedbytheadrenogenitalsyndrome,thepolycysticovarysyndromeorneoplasmsoftheadrenalcortexortheovaries.Duetothefluctuations,repeatedmeasurementsarerecommended.Atherapywithandrogensuppressivedrugscanbefollowedupbytakingcontrols.Inmenwithsignsofprimaryorsecondaryhypogonadism,confirmatorytestosteronelevelscanbedetermined.Testosteronetogetherwithcortisollevelsinstressresearchandsportsmedicinerepresentsausefulparameter.Duetothemanyfactorsthatmayinfluencethetestosteronelevels,itisinsomesituationsadvisabletotakeaprofile.Thereforemeasuringthefreetestosteroneinsalivaisaconvenientmethod,duetotheeasiersamplecollectionwithoutrepeatedvenipunctures.Ifyouneedmoredetailedinformationpleasevisitourwebpagewww.saliva-diagnostics.com.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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