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IBL/soluble α-Klotho ELISA/JP27998/

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Kitsize12x8MethodELISAIncubationtime1x1h,2x30minStandardrange93.75-2000pg/mLSpecimen/Volumes100µlserum,EDTA-plasmaSubstrate/isotopeTMB450nmRegulatoryStatus:ForresearchuseonlyDetailsfor: solubleα-KlothoELISAAnovelmessengerofhealthybodies?!α-Klotho,namedaftertheGreekGoddessofFate,Clotho,whospinsthethreadoflife,wasoriginallycharacterizedasanagingsuppressorgene.OurELISAisperfectlysuitedforthemeasurementoftheproductofthisgene-theα-Klothoprotein.α-Klothoisalsoknownasthemessengerofhealthybodies(FantuzziGFrontImmunol.2014Jul21;5:351).Adefectinklothogeneexpressioninthemouseresultsinasyndromethatresembleshumanageing,includingashortLifespan,infertility,arteriosclerosis,skinatrophy,osteoporosisandemphysema.Theabsenceofα-Klotholeadstoasubstantiallylowerbonedensitythanusual(Kuro-oMetal.Nature.1997Nov6;390(6655):45-51).Picture:α-Klothodeficiencyleadstobonemassdensitylossasthecomparisonofwildtype(left)andα-Klothoknockoutmice(right)demonstrates(picturekindlyprovidedbyDr.YoichiNabeshima,LaboratoryofMolecularScience,InstituteofBiomedicalResearchandInnovation,FoundationforBiomedicalResearchandInnovation,Kobe,Japan)Sincethediscoveryofα-Klotho,whichwasdescribedinthepublicationmentionedabove,severalresearchareashaveemergedwhichbenefitfromthedeterminationofα-Klothointermsofgainingvaluableadditionalinformation:BonemetabolismAgingprocessesNephrologyImmunology,etc.α-KlothoandFGF23arethemainmediatorsofcalciumandphosphatehomeostasis.Anykindofdisturbanceinthisregard,suchasareducedorincreasedproductionofα-Klotho,leadstometabolicbonedisorders(JohnGBetal.AmJKidneyDis.2011Jul;58(1):127-34).Itisalreadyknownthatα-Klotholevelsinblooddecreasewithage(YamazakiYetal.BiochemBiophysResCommun.2010Jul30;398(3):513-8).Lowα-klotholevelsareoftenassociatedwithage-relateddiseases.Theoutcomesofresearchintheareasofbonemetabolismandaging,aswellasthefactthatα-Klothoisproducedexclusivelyinthekidneysandbrain,havepromptedinvestigationsintotheimpactofchangesinα-Klotholevelsinrenaldisease.Studieshaverevealedthatα-klotholevelsaresignificantlydecreasedintheserumalreadyatanearlystageinchronickidneydisease(PavikIetal.NephrolDialTransplant.2013Feb;28(2):352-9).Sincechronickidneydiseasefrequentlyoccurssecondarytoothermedicalconditions,α-KlothoisreceivingincreasingattentionasaMarkeroftheoccurrenceofchronickidneydiseaseinprimarydiseasessuchastype2diabetes(LeeEYetalPLoSOne.2014Aug1;9(8):e102984),wherebythesamplematerialshouldbenoted(seeimagebelow).Figure1:Intype2diabetespatientswithstablerenalfunction,bothplasmaandurineα-Klotholevelsaresignificantlyincreasedcomparedtohealthycontrols.Withdecreasingrenalfunction,shownasalbuminuria,α-Klotholevelsdecreaseinplasmawhileremainingstableinurine.FurThermore,α-Klothoisgainingincreasingattentionasaplayerinmanyimmunologicalprocesses,whichisreflectedintheincreaseofpublicationsonα-Klotho.Figure2:Thenumberofpublicationsonα-KlothohasbeensteADIlyincreasingsince2005.SeparatecontrolsetavailableonrequestForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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