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IBL/Aggrecan/PG (human) ELISA/MG53281/

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MG53281

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Kitsize96MethodELISAIncubationtime1x3h,1x1h,1x15minStandardrange10-250ng/mLSpecimen/Volumes50µLserum,plasma,cellculturesupernatantSubstrate/isotopeTMB450nmRegulatoryStatus:ForresearchuseonlyDetailsfor: Aggrecan/PG(human)ELISAAggrecan(PG)isthepredominantproteoglycanspeciesinarticularcartilage.Itiscomposedofacoreproteinof210kDatowhichover100chondroitinsulfatechains,about20-50keratansulfatechainsandO-linkedaswellasN-linkedoligosaccharidesarecoventlyattached.Thecoreproteincontainsthreedistinctglobulardomains(G1-G3).G1isattheaminoterminus,separatedbyashortextendedsegmentfromG2,whileG3isatthecarboxyterminalend.TheG1aminoterminalregioncaninteractnoncovalentlywithhyaluronicacid(HA)andhasthenbetermedthehyaluronicacidbindingregion(HABR).AlinkproteininteractwithboththeG1regionandtheHAtostABIlizethisinteraction.PGisproducedbychondrocytes,anditsproductionisregulatedbycytokinesandgrowthfactorssuchasIL1β,TNFα,IGF1orTGFβ.Inextracellularmatrix,asmanyas200aggrecanmoleculescanbindtoonesingleHAmoleculetoformanaggregate(MW:5107to5108).Animbalanceinthesynthesisanddegradationofthematrixcomponentsisacommonfeatureofbothosteoarthritisandrheumatoidarthritis.ThelossofPGandothermatrixcomponentsfromthecartilageleadstodestructionofthetissue,causingcompletedeteriorationofthearticularsurface.SeveralrecentpublicationssuggestthatthePGandPGfragmentsreleasedinsynovialfluidandserumduringthedegradationprocessmightserveasMarkersofmetabolicchangesindiseasedcartilage.Cellcultureisacommonlyusedprocedureforthestudyofcartilagemetabolism.ThemeasurementofPGandothermatrixcomponentsinculturesupernatantsandcellularcontentscanassisttheanalysisofofcytokine,growthfactor,drugandpotentialchondroprotectivesubstanceeffectsonthecartilagehomeostasis.IBLInternationalsellsthisELISAforthemeasurementofhumanaggrecantoaidthestudyofthisimportantcartilageconstituent.TheAggrecan/PGELISAisconvenient,highlyspecific,andallowsaccuratemeasurementofPGinsynovialfluid,serumandculturesupernatant.Thisassayisaninterestingtoolfortheexplorationofthecartilagemetabolism.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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