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IBL/IGFBP-2 ELISA/MD58021/

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MD58021

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4000-520-616

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Kitsize12x8MethodELISAIncubationtime1x1h,1x30min,1x15minStandardrange0.2-1680µg/lSpecimen/Volumes15µlSerum,PlasmaSubstrate/isotopeTMB,450nmRegulatoryStatus:EU:CEDetailsfor: IGFBP-2ELISAEnzymeImmunoassayforthequantitativeDeterminationofhumanInsulin-likeGrowthFactorBindingProtein-2(IGFBP-2)inhumanserum,EDTA-plasmacerebrospinalfluid,breastmilk,amnionticfluid,salivaandcellculturemedium.TheadvantagesofourIGFBP-2ELISAare:-measurementoftotalIGFBP-2concentrationinserum,plasmaandinotherhumanbodyfluids-singlestandardswith2,10,20,40and80ng/mL-totalIncubationtimeofonly1.75hours-2ControlsareprovidedforqualitycontrolpurposesaccordingGLP-ready-to-useAntibodyConjugate-nosampleextractionneeded-MicrotiterplateseperatelybreakapartCLINICALIMPLICATIONSTheIGFBP-2concentrationisage-dependentinblood.Normalvaluesforhealthyindividuals(1.5to>70years)wereevaluatedforthisassay.SupplementaryparametertoIGFBP-3inthediagnosisofgrowthdisorders(IGFBP-2/IGFBP-3ratio),IGFBP-2isaninhibitorofgrowthhormoneaction.Progression-dependenttumorMarkerinleukaemia,astrocysticCNStumors,prostate-,suprarenalcortex-,hepatocellularandothercarcinomas.IGFBP-2isalsoananti-agingparameter,asamarkerofphysiologicalfunctionality.Insulin-likegrowthfactors(IGFs)regulatetheproliferation,differentation,apoptose,celladhesionandmetabolisminvarioustissuesandcelltypes.TheIGF-I,whichisproducedmainlyinliverundertheinfluenceofgrowthhormone(GH),regulatesashormonethelineargrowthofthebonesandtheprocessofsexualmaturity,whileIGF-IIismainlyagrowthfactoroffetaltissue.TheBIOLOGicalactionsofIGFovertheIGF-Type-IreceptoraremodulatedvariablythroughtheIGFbindingproteins(IGFBP-1to-6).IGFBP-2is,afterIGFBP-3,thesecondmostfrequentIGFBPinthehumanblood.IGFs,especiallytumortypicalpro-IGF-formsandhormonesregulatetheexpressionofIGFBP-2,GHeffectistherebyinhibiting.AtcellularlevelIGFBP-2seemstostimulatetheproliferationanddisseminationofsolidtumorsviaanIGFindependentmechanism.PHYSIOLOGICALMEANINGIGFBP-2isaunglycosylatedpolypetideof31.3kDa,whichformsbinaryIGF-complexesandshowsnocircADIanrhythminthecirculation.TheserumconcentrationofIGFBP-2increasesinfasting,aftermajorsurgeryandaftertrauma,buttheincreasingoftheconcentrationismostintensiveinmalignantdiseases.ThecorrelationoftheIGFBP-2leveltothedegreeofprogressionisastrikingfeatureinvarioustumortypesasisthenormalizationoftheIGFBPserumlevelsafterremission.DuringtheGH-therapy,e.g.inshortstatureandinGHabuse(doping)theIGFBP-2leveldecreases.InTrisomy18IGFBP-2inmaternalserumisdecreasedandIGFBP-1isincreased;thereforetheratioIGFBP-2/IGFBP-1isamarkerforthischromosomeabnormality.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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