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IBL/Chromogranin A RIA/MI11071/

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Kitsize100MethodRIA(DAb)Incubationtime1x18h,1x45minStandardrange0.156-5nmol/LSpecimen/Volumes50µLserum,plasmaSubstrate/isotope125J<56kBqRegulatoryStatus:EU:CEDetailsfor: ChromograninARIAChromograninsandsecretograninsconstituteafamilyofuniquelyacidicproteinsthatareco-storedwithneurotransmittersandpeptidehormonesinthebrainandthediffuseneuroendocrinesystem(Winkler,H.&Fischer-Colbrie,R.1992).Structurallytheseproteinsareproductsofdifferentgenesbutsharesomeoverallpropertiessuchasanabundanceofacidicaminoacidresiduesandseveralpairsofbasicaminoacidsaspotentialpositionsforpost-translationalcleavage.Chromograninsareco-storedandco-releasedwithneuropeptidesandhormonesintheneuroendocrinecellsthroughoutthebody.Aroleforchromograninsinthegenerationofhormonalgranulesandpackageofhormoneshasbeensuggested.FurThermore,chromograninscanbecleavedintosmallerfragments,whichcandisplayBIOLOGicalactivitiessuchasinhibitionofhormonalrelease,vasodilatationandanti-microbiologicaleffects.TumoursofneuroendocrineoriginusuallypresentwithincreasedplasmalevelsofchromograninA.Theneuroendocrinetumoursarederivedfromtheneuroendocrinecellsandtypicalneuroendocrinetumoursarecarcinoidtumours,pheochromocytomas,neuroblastomas,smallcelllungcancers,hyperparathyroidadenomas,pituitarytumours,prostatecancersandpancreaticislettumoursandincludingtheMEN1andMEN2syndromes.Thisalsoincludesthedifferentneuroendocrinetumoursyndromes,namelythegastrinomas,insulinomas,glucagonomas,somatostatinomas.PPomasandthenon-functioningneuroendocrinetumours(Eriksson,B.etal.2000).Forthesetumours,chromograninAhasbeenshowntobethebestcirculatingMarker(Bajetta,E.etal.1999).ThefirstrADIoimmunoassayformeasurementsofchromograninAwasintroducedin1986(O’Connor,D.T.&Deftos,L.J.1986).SincethenotherassaysformeasurementsofintacthumanchromograninAhavebeenreported.AssaysformeasurementsofdefinedregionsofchromograninAhavealsobeenestablished,suchasspecificmethodsforpancreastatinandotherregionsofchromograninA(Stridsberg,M.2000).ThepresentchromograninAisacompetitivemethodbasedonpolyclonalantibodiesraisedinrabbits.Theantibodieswereraisedagainstapurifiedfragmentcontainingaminoacidsequence116-439inthechromograninAmoleculeandithasbeenshowntomeasurebothintactchromograninAandfragmentsofchromograninA(Stridsberg,M.etal.1993,Stridsberg,M.etal.1995).ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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