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IBL/IGF-1 direct (Somatomedin-C) Radioimmunoassay/MG11171/

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MG11171

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Kitsize96MethodRIA(CT)Incubationtime1x18hStandardrange0.8-70ng/mLSpecimen/Volumes100µLserum,plasmaSubstrate/isotope125I<300kBqRegulatoryStatus:EU:CEDetailsfor: IGF-1direct(Somatomedin-C)RadioimmunoassayRadioimmunoassayfortheinvitroquantitativemeasurementofhumanSomatomedin-C(SM-C)inserumandplasma.BIOLOGicalactivitiesSomatomedin-C(SM-C)orInsulin-likegrowthfactorI(IGF-I)isabasic70aminoacidsinglechainpolypeptide(MW:7649Da)similartoproinsulin(50%sequencehomology),andtotheotherwell-characterizedmemberofthesomatomedinfamily:IGFII(67AA,70%sequencehomologywithIGF-I).SM-Cisthemostimportantfactor,whichmediatesthegrowthpromotingactionsofgrowthhormone,apituitaryhormonewithhighlyfluctuatingbloodlevelsduetopulsatilerelease.ThebloodconcentrationofSM-Cismorestableduetothebindingtocarrierproteins.Theconcentrationofthepredominantbindingprotein(MW53000)aswellastheproductionofSM-C,areregulatedbygrowthhormone.SM-Cisproducedbytheliver,andothertissues,andithasendocrine,paracrineandautocrineactivities.Itstimulatesgrowthandregulatesdifferentiationofvarioustissues,displaysinsulin-likeactivitiesandpromotescartilagegrowth.AlthoughGHisthemostimportantfactorcontrollingSM-Csecretionandconcentration,otherfactorsarealsodeterminant:theage(withapeakatadolescence),thesex,thenutritionalstatus,andotherhormones(oestrogen,thyroxin,prolactin,...).SpecifictrophicstimulimainlycontrolSM-Csecretioninthelocalmicroenvironmentofaparticularorgan(paracrineactivities),whilebloodSM-Cconcentrationisthemostimportantvariableforbalancedsystemicgrowth(endocrineactivities).ClinicalapplicationsGrowthretardationGrowthretardationmaybeduetoseveralcauses,amongwhichdeficientGHproduction(hypopituitarism),whichisassociatedwithlowSM-Cbloodlevels.BecauseofthedifficultiestogetinterpretableresultsfromGHmeasurements(bydynamicmultipleorstimulationtests),thedeterminationofthestableSM-Cconcentrationinplasmaisoftenconsideredasasimplescreeningtesttoevaluation"GHimpregnation"ofthepatientbeforedecidingmoreextensiveinvestigations.Inseveralclinicalsituationswithimpairedgrowth,lowSM-ClevelsmaybeobserveddespitenormalorhighGHproduction(i.e.malnutrition,chronicdiseasesstates,somegeneticdwarfslikePygmies,...).Interestingly,childrenwithdiscreteGHneuro-secreterydysfunctionmaydisplaylowSM-CvaluesdespitenormalGHlevelsbyconventionaltesting.TheresultsofSM-CassaymustbeinterpretedcautiouslybyconsideringthenormalvariationsofSM-Cduringchildhoodandadolescence(seeRosenfeldetal).AcromegalySM-Clevelsareelevatedinacromegaly(excessproductionofGH)andmayserveasanindicatorofdiseaseseverity.Resultsaremorereadilyinterpretedbecausethenormalvaluesaremoreeasilydefinedinadults.SM-Cmeasurementsarealsousefultomonitortreatment.ResearchTheSM-CRIAkitisaninvaluabletooltostudythemodificationsofthisgrowthfactorduringphysiologic(i.e.pregnancy)orpathologic(i.e.diabetes)situations,andthelocalregulationofSM-Cproductioninrelationtoitsparacrineandautocrineactivities(woundhealing,organregeneration,neoplasticgrowth,foetaldevelopment,gonadalregulation,etc).ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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