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IBL/Free Thyroxine (FT4) ELISA/RE55241/

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RE55241

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4000-520-616

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Kitsize12x8MethodELISAIncubationtime60min,15minStandardrange3-70ng/LSpecimen/Volumes50µLserum,plasmaSubstrate/isotopeTMB450nmRegulatoryStatus:EU:CEDetailsfor: FreeThyroxine(FT4)ELISAThethyroidhormone,thyroxine(T4)isproducedbythethyroidgland.Animportantcomponentinthesynthesisisiodine.Themajorformofthyroidhormoneinthebloodisthyroxine(T4).ThyroxineisconvertedtotheactiveT3(threetofourtimesmorepotentthanT4)withincellsbydeiodinases(5"-iodinase).Thyroxine-bindingglobulin(TGB)isthemajorcarrierproteinforcirculatingthyroidhormone.Onlyaverysmallfractionofthecirculatinghormoneisfree(unbound)-T40.03%.Whenthyroidhormoneisbound,itisnotactive,sotheamountofFT3/FT4iswhatisimportant.Forthisreason,measuringtotalthyroxineinthebloodcanbemisleADIng.TheconcentrationoffreethyroidhormonesinthebloodisregulatedbyanegativefeedbackmechanisminvolvingTSH.ThebindingofT4byTBGplaysakeyroleinthisfeedbackmechanismandthemostsignificantchangesthatoccurinT4bindingcapacityaretheresultofalterationsinTBG.ChangesinthecirculatinglevelsofTBGwillresultinaproportionalincreaseordecreaseintheconcentrationoftotalT4.However,measurementofserumFT4isunaffectedbychangesinT4proteinbindinglevelsandthereforecorrelateswellwiththefunctionalthyroidstateinmostindividuals.FactorsresponsIBLefordiscrepanciesbetweenserumtotalT4levelsandtruethyroidstatesincludeTBGconcentration,estrogenichormones(pregnancy,oralcontraceptivesandestrogen)anddrugsthatbindtoTBGpreventingitsbindingtoFT4Thethyroninesactonthebodytoincreasethebasalmetabolicrate,affectproteinsynthesisandincreasethebody"ssensitivitytocatecholamines(suchasadrenaline)bypermissiveness.Thethyroidhormonesareessentialtoproperdevelopmentanddifferentiationofallcellsofthehumanbody.Thesehormonesalsoregulateprotein,fat,andcarbohydratemetabolism,affectinghowhumancellsuseenergeticcompounds.Numerousphysiologicalandpathologicalstimuliinfluencethyroidhormonesynthesis.Thyrotoxicosisorhyperthyroidismistheclinicalsyndromecausedbyanexcessofcirculatingfreethyroxine,freetriiodothyronine,orboth.BothT3andT4areusedtotreatthyroidhormonedeficiency(hypothyroidism).ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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