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IBL/Free Triiodthyronine (FT3) ELISA/RE55231/

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RE55231

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Kitsize12x8MethodELISAIncubationtime60min,15minStandardrange0.4-18pg/mLSpecimen/Volumes50µLserum,plasmaSubstrate/isotopeTMBRegulatoryStatus:EU:CEDetailsfor: FreeTriiodthyronine(FT3)ELISAThethyroidhormone,triiodothyronine(T3),isproducedbythethyroidgland.Animportantcomponentinthesynthesisisiodine.ThyroxineisconvertedtotheactiveT3(threetofourtimesmorepotentthanT4)withincellsbydeiodinases(5"-iodinase).Thyroxine-bindingglobulin(TGB)isthemajorcarrierproteinforcirculatingthyroidhormone.Onlyaverysmallfractionofthecirculatinghormoneisfree(unbound)0.3%.hisfractionisBIOLOGicallyactive.Thus,measurementsoffreetriiodothyronineconcentrationscorrelatemorereliablywithclinicalstatusthantotaltriiodothyroninelevels.Forexample,theincreaseintotaltriiodothyroninelevelsassociatedwithpregnancy,oralcontraceptivesandoestrogentherapyresultinhighertotalT3levelswhilethefreeT3(FT3)concentrationremainsbasicallyunchanged.Theconcentrationsofthecarrierproteinsarealteredinmanyclinicalconditions,suchaspregnancy.Innormalthyroidfunctionastheconcentrationsofthecarrierproteinsalters,thetotaltriiodothyroninelevelchangessothatthefreetriiodothyronineconcentrationremainsconstant.ThebindingofT3playsakeyroleinthefeedbackcontrolofthethyroid,withFT3actingonthepituitarytoinhibitthyroidhormonesecretion.Thethyroninesactonthebodytoincreasethebasalmetabolicrate,affectproteinsynthesisandincreasethebody"ssensitivitytocatecholamine(suchasadrenaline).Thethyroidhormonesareessentialtoproperdevelopmentanddifferentiationofallcellsofthehumanbody.Thesehormonesalsoregulateprotein,fat,andcarbohydratemetabolism,affectinghowhumancellsuseenergeticcompounds.Numerousphysiologicalandpathologicalstimuliinfluencethyroidhormonesynthesis.Thyrotoxicosisorhyperthyroidismistheclinicalsyndromecausedbyanexcessofcirculatingfreethyroxine,freetriiodothyronine,orboth.BothT3andT4areusedtotreatthyroidhormonedeficiency(hypothyroidism).Sinceconditionssuchaspregnancy,oestrogentherapyandothernon-thyroidfactorsalterTBGconcentrations,assessmentofthyroidfunctionthroughtotalT3measurementmayresultinanerroneousdiagnosis,becauseFT3levels,areunaffectedbybindingproteinchanges.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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