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IBL/TSH ELISA/RE55221/

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RE55221

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4000-520-616

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Kitsize12x8MethodELISAIncubationtime10min,90min,20minStandardrange0,25-15mIU/LSpecimen/Volumes25µLSerumSubstrate/isotopeTMB450nmRegulatoryStatus:EU:CEDetailsfor: TSHELISAMeasurementoftheserumconcentrationofthyrotropin(TSH),aglycoproteinwithamolecularweightof28,000daltonsandsecretedfromtheanteriorpituitary,isgenerallyre¬gardedasthemostsensitiveindicatoravailableforthediagnosisofprimaryandsecondary(pituitary)hypothyroidism(1,2).IncreaseinserumconcentrationsofTSH,whichisprimarilyresponsIBLeforthesynthesisandreleaseofthyroidhormones,isanearlyandsensitiveindicatorofdecreasethyroidreserveandinconjunctionwithdecreasedthyroxine(T4)concentrationsisdiagnosticofprimaryhypothyroidism.TheexpectedincreaseinTSHconcentrationsdemonstratestheclassicalnegativefeedbacksystembetweenthepituitaryandthyroidglands.Thatis,primarythyroidglandfailurereducessecretionofthethyroidhormones,whichinturnstimulatesthereleaseofTSHfromthepituitary.Additionally,TSHmeasurementsareequallyusefulindifferentiatingsecondaryandtertiary(hypothalamic)hypothyroidismfromtheprimarythyroiddisease.TSHreleasefromthepituitaryisregulatedbythyrotropinreleasingfactor(TRH),whichissecretedbythehypothalamus,andbydirectactionofT4andtriiodothyronine(T3),thethyroidhormones,atthepituitary.IncreaselevelsofT3andT4reducestheresponseofthepituitarytothestimulatoryeffectsofTRH.Insecondaryandtertiaryhypothyroidism,concentrationsofT4areusuallylowandTSHlevelsaregenerallylowornormal.EitherpituitaryTSHdeficiency(secondaryhypothyroidism)orinsufficiencyofstimulationofthepituitarybyTRH(tertiaryhypothyroidism)causesthis.TheTRHstimulationtestdifferentiatestheseconditions.Insecondaryhypothyroidism,TSHresponsetoTRHisbluntedwhileanormalordelayedresponseisobtainedintertiaryhypothyroidism.Further,theadventofimmunoenzymometricassayshasprovidedthelaboratorywithsufficientsensitivitytoenablethedifferentiatingofhyperthyroidismfromeuthyroidpopulationandextendingtheusefulnessofTSHmeasurements.Thismethodisasecond-generationassay,whichprovidethemeansfordiscriminationinthehyperthyroid-euthyroidrange.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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