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IBL/Amyloid-beta (1-40) CSF ELISA/RE59651/

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Kitsize12x8MethodELISAIncubationtime1x2h,1x1h,1x30min.Standardrange188-1880pg/mLSpecimen/Volumes5µLCSFSubstrate/isotopeTMB450nmRegulatoryStatus:EU:CEDetailsfor: Amyloid-beta(1-40)CSFELISAIn2010,thenumberofdementiapatientsworldwidewasestimatedat36million.Assuminganongoinglackofsufficientpreventiveandcurativetreatments,thisisexpectedtodoubleevery20years.Alzheimer’sDiseaseaccountsforroughly60-70%ofalldementiacases.Bothprevalenceandincidenceincreasewithage.Prevalenceisaround1%inthoseaged65-69,andmorethan30%inthoseaged90orolder.ThedevelopmentoftheDiseaseischaracterizedbythreestages,asdefinedbytheUSNationalInstituteonAgingworkgroups.ApreclinicalstageofAlzheimer’sDisease,themildcognitiveimpairment(MCI)stageduetoAD,andthedementiastageduetoAD[9-11].Amyloidosisoccursasearlyasthepreclinicalstage.ThefirstcognitivedeficitscanmanifestthemselvesinMCIstage,whileinthedementiastagepatientsareunabletodoanyworkordailychores.Theconcentrationofamyloid-beta(1-42)isthereforerecognizedasausefulbioMarker(incombinationwithotherbiomarkerssuchasTauandPhospho-Tau)indiagnosingAlzheimer’sDisease.Moreover,anumberofindependentstudies(forexample[3-5])showedtheratioofamyloid-beta(1-42)toamyloid-beta(1-40)tobeasuperiordiagnosticmarkerforAlzheimer’sDisease.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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