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IBL/Amyloid-beta (1-42) High Sensitive ELISA/RE59791/

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RE59791

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4000-520-616

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Kitsize12x8MethodELISAIncubationtime1x18h,1x1h,1x30min.Standardrange1.56-100pg/mLSpecimen/Volumes100µLEDTA-plasma,CSF,cellculturesupernatantSubstrate/isotopeTMB450nmRegulatoryStatus:ForresearchuseonlyDetailsfor: Amyloid-beta(1-42)HighSensitiveELISAPreviouslysoldasJP27719Amyloid-beta(1-42)(FL)ELISA.SincetwohighlyspecificantibodiesagainsteachofC-andN-terminusofHumanAβ(1-42)areusedinthiskit,itcanmeasurefull-lengthmoleculesofHumanAβ(1-42)withhighspecificityandsensitivity.ThefirstcaseofAlzheimer"sdiseasewasdefinedandreportedin1907bytheGermanscientist,Dr.A.Alzheimer.Hisstudieshaveshownthatthisisthemaincauseofdementiaintheelderly.TheplaqueswhichappearinthebrainsofAlzheimer"sdiseasepatientsaremostlyconstitutedbytheAmyloidβprotein(Aβ).Aβisapeptidewhichconsistsof40or42(43)aminoacids,andreportsshowthatthesearecleavedbyβ-andγ-secretasefromtheamyloidprecursorprotein(APP).APPisatrans-membraneproteinconsistingof695,751,or770aminoacids.Reportshaveshown,thatmanyvariantsofAβexistandareclarifiedintotheculturesupernatantfromAPPCDNAtransfectedmouseneuroblastomacells.FurThermore,in1995,adominantanddifferentialdepositionofdistinctβamyloidpeptidespecies,Aβ(N3pE),insenileplaqueswasfoundbySaidoetal.Thismodifiedmolecule,startingatthe3rdaminoterminalresidue,glutamate,wasdiscoveredtoconverttopyroglutamatethroughintramoleculardehydration.SincetwohighlyspecificantibodiesagainsteachofC-andN-terminusofHumanAβ(1-42)areusedinthiskit,itcanmeasurefull-lengthmoleculesofHumanAβ(1-42)withhighspecificityandsensitivity.ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.

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