999986 | 4ME 16:0 Diether DG1,2-di-O-phytanyl-sn-glycerolInfo4ME 16:0 Diether DG1,2-di-O-phytanyl-sn-glycerolIn biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane. (See References) Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.Precaution: Since short chain Diacylglycerols mimic effects of the tumor-promoting phorbol diesters in a number of biological systems, extra care should be employed in their handling. Treatment of solutions, vessels and other articles with 1N NaOH before washing or discarding will destroy diacylglycerols.Storage:Diacylglycerols are conveniently stored in chloroform solutions in glass vials with teflon-lined caps at -20°C. Under these conditions acyl migration is minimal. Avoid plastic when handling chloroform solutions.Delivery to cells:Dry samples of diacylglycerol in chloroform, using a stream of nitrogen. Dissolve the residue in an appropriate volume of ethanol or DMSO, then dilute to the desired aqueous medium.Effective concentration:Most biological responses saturate at 20 to 250 µM sn-1,2-dioctanoylglycerol. Only sn-1,2 isomers appear to be active.DataHygroscopicNoLight SensitiveNoMolecular FormulaC43H88O3Percent CompositionC 79.07%, H 13.58%, O 7.35%Purity>99%Stability1 YearsStorage Temperature-20°CCAS Number99341-19-2 CAS Registry Number is a Registered Trademark of the American Chemical SocietyFormulaWeight653.157Exact Mass652.673Synonyms<p>archaeol1,2-di-(3,7,11,15-tetramethylhexadecyl)-sn-glycerolDG(16:0(3me,7me,11me,15me)e/16:0(3me,7me,11me,15me)e)/0:0)</p>DownloadsChemDraw File3D StructureStructureSafety Data SheetSafety Data SheetReferencesIaea DB, Spahr ZR, Singh RK, Chan RB, Zhou B, Bareja R, Elemento O, Di Paolo G, Zhang X, Maxfield FR. Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158609. doi: 10.1016/j.bbalip.2020.158609. Epub 2020 Jan 7. PMID: 31917335; PMCID: PMC6996790.PubMed ID: 31917335Meyer S, Thiel V, Joergensen RG, Sundrum A. Relationships between feeding and microbial faeces indices in dairy cows at different milk yield levels. PLoS One. 2019 Aug 20;14(8):e0221266. doi: 10.1371/journal.pone.0221266. eCollection 2019.PubMed ID: 31430322Lorem ipsum dolor sit amet, omnis melius gloriatur at his, veri exerci conclusionemque pro eu, simul possit ancillae an vix. Ut case iudico pro, vero necessitatibus te quo, ea sit regione appetere. Exerci persequeris pro in, usu brute iudico erroribus at. Quem posse nostro eam ei, at tale iriure admodum sed.Certificates of AnalysisCertificate of Analysis(Lot No. 999986C-50MG-A-013and 6396OKA013) Certificate of Analysis(Lot No. 999986C-5MG-A-013and 6396CHA013) Certificate of Analysis(Lot No. 999986O-50MG-A-013and 6396OKA013) Certificate of Analysis(Lot No. 999986O-5MG-A-013and 6396OHA013) Certificate of Analysis(Lot No. 999986C-200MG-A-013and 6396CNA013) Certificate of Analysis(Lot No. 999986O-200MG-A-013and 6396ONA013) Certificate of Analysis(Lot No. 999986O-200MG-B-013and 6396ONB013) Certificate of Analysis(Lot No. 999986C-5MG-B-013and 6396CHB013) Certificate of Analysis(Lot No. 999986O-5MG-A-014and 6396OHA014) [v-cloak] {display: none;}@media only screen and (min-width: 768px) {#product-config {display:flex;width:100%;}}Base Price:${originalprice|money}Custom Packaging:(${concentration} @$4.00/ea. + $100)${custompackagingtotal|money}Packaging:${concentration}Item Total:${totalprice|money}(Sales Tax may apply)Please select an option above.Selected Product${sku} - ${concentration}Add to Cart
Avanti Polar Lipids
阿凡提极地脂质公司，有着50年的历史，创造了最高纯度的脂类产品。我们对高质量和独特的产品的热情只会被我们在市场上的良好声誉所超越。
Since its spartan beginnings in a 900 square foot rented laboratory space, Avanti has established a 25 acre manufacturing campus comprised of 11 buildings which house our manufacturing, formulation, analytical, and administrative units. Operations were moved to the current site in Alabaster, Alabama, in 1990, and we have continued to expand our capabilities and attract talented personnel to develop new and innovative products. With over 120 employees diligently working to provide high quality revolutionary lipid products, we have successfully grown our product offering to well over 2000 unique lipids, antibodies, and lipid research tools while maintaining the founding vision established by Dr. Shaw in 1967. Quite an accomplishment considering we started with a catalog containing only a handful of lipids isolated from plant and animal sources.
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货号
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名称
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规格
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Avanti Polar Lipids
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860853
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16:0 Azido Coenzyme A
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1mg
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Avanti Polar Lipids
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900415
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Oleic Acid (18-azido)
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5mg 25mg
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Avanti Polar Lipids
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900414
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16:0(alkyne)-18:1 PE
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1mg 5mg
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Avanti Polar Lipids
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900413
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16:0(alkyne)-18:1 PC
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1mg 5mg
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Avanti Polar Lipids
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860831
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C6(6-azido) Ceramide
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5mg
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Avanti Polar Lipids
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860832
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C6(6-azido) LacCer
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5mg
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Avanti Polar Lipids
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860833
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C6(6-azido) GalCer
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5mg
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Avanti Polar Lipids
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860834
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C6(6-azido) GluCer
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5mg
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Avanti Polar Lipids
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900600
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PhotoClick Sphingosine
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100ug 250ug
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Avanti Polar Lipids
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810340
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Click PI(4,5)P2-azido
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100ug
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Avanti Polar Lipids
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900400
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Palmitic acid (15-yne)
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1mg 5mg
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Avanti Polar Lipids
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900404
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pacFA Ceramide
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1mg
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Avanti Polar Lipids
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900405
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pacFA GlcCer
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1mg
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Avanti Polar Lipids
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900406
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pacFA GalCer
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1mg
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Avanti Polar Lipids
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900407
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16:0-pacFA PC
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1mg
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