提醒:代购产品,无质量问题不接受退换货,下单前请仔细核对信息。下单后请及时联系客服
核对商品价格,订单生效后再付款。
Smartox/Selective blocker of insects calcium channels/ITO001-00100/0.1mg
价格:
自营商城
解放采购
正品保障
及时交付
厂家直采
一站服务
货号:
品牌:
会员服务:
尊享会员价
贵宾专线
运费优惠
闪电退款
福利优惠
上门换新
友情提示
以上价格仅为参考,请联系客服询价。
免费咨询热线
4000-520-616
产品说明
ω-Tbo-IT1 has been isolated from the venom of the Tibellus oblongus spider. ω-Tbo-IT1 is a selective blocker of insects calcium channels. It has been shown that ω-Tbo-IT1 has a potent insect toxicity with LD50 19 μg/g on house fly Musca domestica larvae and LD50 20 μg/g on juvenile Gromphadorhina portentosa cockroaches. Electrophysiological experiments revealed a reversible inhibition of evoked excitatory postsynaptic currents in blow fly Calliphora vicina neuromuscular junctions with an IC50 value 40 ± 10 nM.
Description:
Product code: ITO001.
Category: High voltage-gated Ca2+ channels.
AA sequence: CASKNERCGNALYGTKGPGCCNGKCICRTVPRKGVNSCRCM-NH2
Disulfide bridges: C1-C21; C8-C25; C20-C40
Length (aa): 41
Formula: C171H285N61O53S9
Molecular weight: 4331,74 g/mol
Appearance: White lyophilized solid
Solubility: water and saline buffer
CAS number:
Source: Synthetic
Purity rate: > 95 %
Reference:ω-Tbo-IT1–New Inhibitor of Insect Calcium Channels Isolated from Spider Venom Mikov A., et al. (2015) ω-Tbo-IT1–New Inhibitor of Insect Calcium Channels Isolated from Spider Venom. Sci Rep.
Novel disulfide-containing polypeptide toxin was discovered in the venom of the Tibellus oblongus spider. We report on isolation, spatial structure determination and electrophysiological characterization of this 41-residue toxin, called ω-Tbo-IT1. It has an insect-toxic effect with LD50 19 μg/g in experiments on house fly Musca domestica larvae and with LD50 20 μg/g on juvenile.
PMC: 4661699
Smartox Biotechnology 是全球唯一一家专门生产动物毒液多肽毒素,用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。Smartox Biotechnology 于 2009 年由来自 Grenoble 神经科学研究所 (Grenoble Institute of Neuroscience) 的 Michel de waard 博士创立, Smartox Biotechnology 专门研究动物毒液,制作合成多种毒液中的多肽成分(常称为毒素)。 De Waard 博士研究离子通道与毒素多肽的关系,尤其是鉴定、开发毒素多肽作为治疗性分子或细胞穿透肽 (cell penetrating peptides, CPP) 。其研究团队在毒液分离,药理性活性肽鉴定、富半胱氨酸肽定性、制作和优化等方面具有独特、丰富的经验。 2010 年, Smartox Biotechnolgy 被法国研究部 (Ministry of Research) 授予“新兴企业 OSEO 奖 (OSEO prize for emerging businesses) ”。
新品排行榜
1
Smartox//12IBX001-00500/0.5mg
2
Smartox/ω Conotoxin MVII...
3
Smartox/Selective blocker of Na<...
4
Smartox/Blocker of Kv...
5
Smartox/Selective blocker of N-t...
6
Smartox//PTF004-00010/0.01mg
7
Smartox/Blocker of Kv...
8
Smartox/ASIC1a selective blocker...
9
Smartox/Selective blocker of ins...
10
Smartox/Selective blocker of mec...
文章排行榜
1
Smartox Biotechnology smartox-biotech|产品详情|进口试剂采购网
2
smartox-biotech【上等代理】141029 smartox-biotech公司
3
Smartox/Huwentoxin-XVI is a selective blocker of N-type Ca2+ channels/HWT016-00100/0.1mg
4
Smartox/Blocker of Kv2 channels/SCT01-50010/5x.0.01mg
5
特硫平 Q | smartox-biotech代理
6
smartox 多肽毒素_化学试剂_行业专用试剂_生化与分子生物学用试剂...
7
Smartox/TTX-S selective blocker/08HWT002-00100/0.1mg
8
Smartox/TTX-S selective blocker/HWF002-00100/0.1mg
9
ω-芋螺毒素-GVIA | Smartox产品
10
海南毒素-III | Smartox