提醒：代购产品，无质量问题不接受退换货，下单前请仔细核对信息。下单后请及时联系客服
核对商品价格，订单生效后再付款。
Smartox/Fluorescent (red) Kv1.3 blocker/SAT001-00100/1mg
价格：
自营商城
解放采购
正品保障
及时交付
厂家直采
一站服务
货号：
品牌：
会员服务：
尊享会员价
贵宾专线
运费优惠
闪电退款
福利优惠
上门换新
友情提示
以上价格仅为参考，请联系客服询价。
免费咨询热线
4000-520-616
产品说明
TMR-ShK peptidetoxinisasyntheticderivativeofthewell-known ShKtoxin(Stichodactylahelianthusneurotoxin) isolatedfromthevenomoftheCarribeanseaanemone Stoichactishelianthus.Wild-type ShK blockspotentlyKv1.3(KCNA3),Kv1.1(KCNA1),Kv1.4(KCNA4)andKv1.6(KCNA6)withaKdvalueof11pM,16pM,312pMand165pM,respectively.ThefluorescentTMR-labeledShKblocksKv1.3andKv1.1withKdvaluesof52pMand397pM,respectively. TMR-ShK canbeusedtoidentifylymphocytesexpressingKv1.3channelssuchaseffectivememoryTcells(TEM)inthecaseofautoimmunediseases(type1diabetes,mellitusorrheumatoidarthritis)whichoverexpressKv1.3channels.Description:Productcode:SAT001-00100.Categories:Kv1.3channel,Potassiumchannels.Tags:Kv1.3,TRAM-34.AAsequence: TMR-AEEAc-Arg-Ser-Cys3-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys12-Thr-Ala-Phe-Gln-Cys17-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys28-Arg-Lys-Thr-Cys32-Gly-Thr-Cys35-OHDisulfidebonds: Cys3-Cys35,Cys12-Cys28 andCys17-Cys32Length(aa): 35Formula: C200H310N57O55S7MolecularWeight: 4611.7DaAppearance:redlyophilizedsolidSolubility: waterorsalinebufferCASnumber: NASource: SyntheticPurityrate: >97%TMRfluorescentdye (5(6)-TAMRA): λex543nM, λem572nMReference:ANovelFluorescentToxintoDetectandInvestigateKv1.3ChannelUp-regulationinChronicallyActivatedTLymphocytesTlymphocyteswithunusuallyhighexpressionofthevoltage-gatedKv1.3channel(Kv1.3(high)cells)havebeenimplicatedinthepathogenesisofexperimentalautoimmuneencephalomyelitis,ananimalmodelformultiplesclerosis.WehavedevelopedafluoresceinatedanalogofShK(ShK-F6CA),themostpotentknowninhibitorofKv1.3,fordetectionofKv1.3(high)cellsbyflowcytometry.ShK-F6CAblockedKv1.3atpicomolarconcentrationswithaHillcoefficientof1andexhibited>80-foldspecificityforKv1.3overKv1.1andotherK(V)channels.Inflowcytometryexperiments,ShK-F6CAspecificallystainedKv1.3-expressingcellswithadetectionlimitofapproximately600channelspercell.RatandhumanTcellsthathadbeenrepeatedlystimulated7-10timeswithantigenwerereADIlydistinguishedonthebasisoftheirhighlevelsofKv1.3channels(>600channels/cell)andShK-F6CAstainingfromrestingTcellsorcellsthathadundergone1-3roundsofactivation.FunctionalKv1.3expressionlevelsincreasedsubstantiallyinamyelin-specificratTcelllinefollowingmyelinantigenstimulation,peakingat15-20handthendecliningtobaselineoverthenext7days,inparallelwiththeacquisitionandlossofencephalitogenicity.Bothcalcium-andproteinkinaseC-dependentpathwayswererequiredfortheantigen-inducedKv1.3up-regulation.ShK-F6CAmightbeusefulforrapidandquantitativedetectionofKv1.3(high)expressingcellsinnormalanddiseasedtissues,andtovisualizethedistributionoffunctionalchannelsinintactcells.BeetonC.,etal.(2003)ANovelFluorescentToxintoDetectandInvestigateKv1.3ChannelUp-regulationinChronicallyActivatedTLymphocytes.JBC.PMID:12511563
Smartox Biotechnology 是全球唯一一家专门生产动物毒液多肽毒素，用于细胞离子通道功能研究的生物医药公司。多肽毒素在生物制药领域具有重要的使用价值。Smartox Biotechnology 于 2009 年由来自 Grenoble 神经科学研究所 (Grenoble Institute of Neuroscience) 的 Michel de waard 博士创立, Smartox Biotechnology 专门研究动物毒液，制作合成多种毒液中的多肽成分（常称为毒素）。 De Waard 博士研究离子通道与毒素多肽的关系，尤其是鉴定、开发毒素多肽作为治疗性分子或细胞穿透肽 (cell penetrating peptides, CPP) 。其研究团队在毒液分离，药理性活性肽鉴定、富半胱氨酸肽定性、制作和优化等方面具有独特、丰富的经验。 2010 年， Smartox Biotechnolgy 被法国研究部 (Ministry of Research) 授予“新兴企业 OSEO 奖 (OSEO prize for emerging businesses) ”。
新品排行榜
1
Smartox//12IBX001-00500/0.5mg
2
Smartox/ω Conotoxin MVII...
3
Smartox/Selective blocker of Na<...
4
Smartox/Blocker of Kv...
5
Smartox/Selective blocker of N-t...
6
Smartox//PTF004-00010/0.01mg
7
Smartox/Blocker of Kv...
8
Smartox/ASIC1a selective blocker...
9
Smartox/Selective blocker of ins...
10
Smartox/Selective blocker of mec...
文章排行榜
1
Smartox Biotechnology smartox-biotech|产品详情|进口试剂采购网
2
smartox-biotech【上等代理】141029 smartox-biotech公司
3
Smartox/Huwentoxin-XVI is a selective blocker of N-type Ca2+ channels/HWT016-00100/0.1mg
4
Smartox/Blocker of Kv2 channels/SCT01-50010/5x.0.01mg
5
特硫平 Q | smartox-biotech代理
6
smartox 多肽毒素_化学试剂_行业专用试剂_生化与分子生物学用试剂...
7
Smartox/TTX-S selective blocker/08HWT002-00100/0.1mg
8
Smartox/TTX-S selective blocker/HWF002-00100/0.1mg
9
ω-芋螺毒素-GVIA | Smartox产品
10
海南毒素-III | Smartox
