首页 > Adipogen > Adipogen/20S Proteasome Assay Kit (SDS Activation Format)/AG-44T-0100-KI01/1 Kit

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Adipogen/20S Proteasome Assay Kit (SDS Activation Format)/AG-44T-0100-KI01/1 Kit

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AG-44T-0100-KI01

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Adipogen

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Specifications&Handling:PropertiesCrossreactivityRabbitKitContains25μgofEnzymeSolution(20SProteasome)250μlofActivationSolution50μlofSubstrateSuc-LLVY-AMCSolution2x1.5mlofReactionBufferNote:Kitcontainsreagentssufficientfor96x200μlreactions.OtherProductDataUse:Thiskitcontainsbuffersandreagentsforthequantitativeanalysisof20Sproteasomeactivityincuvettesora96-wellmicrotiterplateformats.The20SactivityismeasuredbymonitoringthereleaseoffreeAMCfromthefluorogenicpeptideSuc-Leu-Leu-Val-Tyr-AMC.TherateofAMCreleasemaybemeasuredeitherbyabsorbanceorfluorescenceovertime.NOTE:Pleasereadinstructionscompletelypriortoperformingtheassay.OriginManufacturedbyBostonBiochemProductTypeKitShippingandHandlingShippingDRYICEShortTermStorage-20°CLongTermStorage-80°CHandlingAdviceAliquottoavoidfreeze/thawcycles.Use/StABIlityStableforatleast1yearafterreceiptwhenstoredat-80°C.DocumentsManualDownloadDescription:The20SProteasomeisthecatalyticcorecomponentofthemulti-complex26SProteasomethatselectivelydegradesintracellularproteins.Itiscommonlyassociatedwithregulatorycomplexes,whichincludethe19SProteasome,thePA28α/βcomplex,orthePA28γcomplex.The20SProteasomeiscomposedof28subunitsarrangedintofourstackedrings.Theouterrings,containingsevensubunitseach,arecomposedofclosely-relatedbutnon-identicalαsubunits.Theamino-terminaltailsoftheαsubunitsformagatethatrestrictssubstrateentryintothecatalyticcore.Theinnerrings,alsocontainingsevensubunitseach,arecomposedofclosely-relatedbutnon-identicalβsubunits.Theamino-terminaltailsofsixoftheβsubunits,threeperring,haveproteolyticactivity.Inhibitionof20SProteasomeproteolyticcoreactivityusingsmallmoleculeinhibitorsisavaluabletoolforthefunctionalstudyofavarietyofproteinsandfortherapeuticintervention.The20SProteasomecanbeactivatedchemicallybytheadditionofdetergentorbytheproteinaceousactivatorPA28activatorα.

Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。