首页 > Adipogen > Adipogen/Ganglioside GM1 . sodium salt/AG-CN2-9000-M005/5 mg

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Adipogen/Ganglioside GM1 . sodium salt/AG-CN2-9000-M005/5 mg

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AG-CN2-9000-M005

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Adipogen

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MoreInformationProductDetailsSynonymsGM1.Na;MonosialogangliosideGM1.NaProductTypeChemicalPropertiesFormulaC73H130N3O31.NaMW1545.8.23.0(calculatedonsphingosineC18:1andstearicacid)SequenceStructure:II3Neu5AcGgOse4Cer;β-Gal-(1-3)-β-GalNAc-(1-4)-[α-Neu5Ac-(2-3)-]β-Gal-(1-4)-β-Glc-(1-1)-Cer;Cer:SphingosineC18:1-C20:1,~1:1byvol.;stearicacidover90%MerckIndex14:4364CAS37758-47-7Source/HostChemicalsIsolatedfrombovinebrain.PurityChemicals≥98%(TLC)SolubilitySolubleinwater(micellaraggregates)orchloroform:methanol(2:1).FormulationLyophilized.EndotoxinContentNotdetectable.IdentityDeterminedby1H-NMR,MSandHPTLC.InChiKeyLFNNYGUBFYVSKX-FPEJYKFLSA-MShippingandHandlingShippingAMBIENTShortTermStorage+4°CLongTermStorage-20°CHandlingAdviceHygroscopic.Protectfrommoisture.Use/StABIlityStableforatleast2yearsafterreceiptwhenstoredat-20°C.DocumentsMSDSDownloadPDFProductSpecificationSheetDatasheetDownloadPDFGangliosidesareacidicglycosphingolipidsthatformlipidraftsintheouterleafletofthecellplasmamembrane,especiallyinneuronalcellsinthecentralnervoussystem.Theyparticipateincellularproliferation,differentiation,adhesion,signaltransduction,cell-to-cellinteractions,tumOrigenesisandmetastasis.Theaccumulationofgangliosideshasbeenlinkedtoseveraldiseases.GangliosideGM1isamajorsialoglycolipidofneuronalmembranesthatmodulatescalciumhomeostasisandwhichisimportantforneuronalplasticityandrepairmechanisms.ItbindstocholeratoxinBsubunit,resultinginstimulationofadenylylcyclaseinawidevarietyofcelltypes.AftercholeratoxinbindstomembraneassociatedMonosialogangliosideGM1,theAsubunitofcholeratoxinistranslocatedtothecellinterior,whereitcatalyzestheADPribosylationofthemembraneassociatedGssubunitofadenylylcyclase.Inaddition,bindingofcholeratoxintomonosialogangliosideGM1causestranslocationofNF-κBandactivationofdendriticcells.E.coliheat-labileenterotoxin(LT)isstructurallyandfunctionallysimilartocholeratoxinandbindsGM1aswell.GM1hasalsobeenshowntoimproveParkinson"sdiseasesymptomsandslowit"sprogression.ProductReferencesRoleofmembranegangliosidesinthebindingandactionofbacterialtoxins:P.H.Fishman;J.Membr.Biol.69,85(1982)Promotionofneuritogenesisinmouseneuroblastomacellsbyexogenousgangliosides.RelationshipbetweentheeffectsandthecellsassociationofgangliosideGM1:L.Facci,etal.;J.NeuRochem.42,299(1984)AbacteriumlipopolysaccharidethatelicitsGuillain-BarrésyndromehasaGM1ganglioside-likestructure:N.Yuki,etal.;J.Exp.Med.178,1771(1993)GangliosideGM1bindstotheTrkproteinandregulatesreceptorfunction:T.Mutoh,etal.;PNAS92,5087(1995)Dynamicandstructuralpropertiesofsphingolipidsasdrivingforcetotheformationofmembranedomains:S.Sonnino,etal.;Chem.Rev.106,2111(2006)GM1gangliosideinParkinson"sdisease:Resultsofafiveyearopenstudy:J.S.Schneider,etal.;J.Neurol.Sci.292,45(2010)Heat-LabileEnterotoxin:BeyondGM1Binding:B.Mudrak&M.J.Kuehn;Toxins2,1445(2010)Newfindingsonnucleargangliosides:overviewonmetabolismandfunction:R.Ledeen&G.Wu;J.Neurochem.116,714(2011)BindingofCFA/IpiliofenterotoxigenicEscherichiacolitoAsialo-GM1ismediatedbytheminorpilinCfaE:T.P.Madhavan,etal.;Infect.Immun.84,1642(2016)PhenotypicAnalysisRevealsthatthe2010HaitiCholeraEpidemicIsLinkedtoaHypervirulentStrain:K.J.F.Satchell,etal.;Infect.Immun.84,2473(2016)

Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。