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Adipogen/Ubiquitin vinyl sulfone (human) (rec.)/SBB-PS0032-C050/50 µg

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SBB-PS0032-C050

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Adipogen

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MoreInformationProductDetailsProductTypeProteinPropertiesSource/HostE.coliSequenceHumanubiquitin(aa1-76)(AccessionNr.P0CG47)withaC-terminalvinylsulfonegroup.CrossreactivityHumanApplicationTypicalworkingconcentrationrangeis1-5μM.Reactionconditionswillneedtobeoptimizedforeachspecificapplication.MW~9kDaPurity≥97%(LCMS)ConcentrationLotdependent.AccessionNumberP0CG47FormulationLiquid.In50mMMESpH6.0,100mMsodiumchloride.OtherProductDataClickhereforaTypicalLot-specificProductDatasheetfromtheOriginalManufacturerOurproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.DeclarationManufacturedbySouthBayBio.ShippingandHandlingShippingDRYICEShortTermStorage-20°CLongTermStorage-80°CHandlingAdviceAliquottoavoidfreeze/thawcycles.Use/StABIlityStableforatleast1yearafterreceiptwhenstoredat-80°C.DocumentsMSDSNoProductSpecificationSheetDatasheetDownloadPDFUbiquitinisasmall(8.5kDa)regulatoryproteinthathasbeenfoundinalmostalltissuesofeukaryoticorganisms.Theadditionofubiquitintoasubstrateproteiniscalledubiquitinationorubiquitylation.Ubiquitinationcanaffectproteinsinmanyways:itcansignalfortheirdegradationviatheproteasome,altertheircellularlocation,affecttheiractivityandpromoteorpreventproteininteractions.Removalofubiquitinfromasubstrateproteinoccursviadeconjugatingenzymes,ofwhichtherearenearly100knownenzymeswithvariouslinkagespecificities.Thisproductconsistsofafull-lengthhuman,matureubiquitinpolypeptide(aminoacids1-76),expressedinE.coliwithaC-terminalwarhead(VinylSulfone).Ubiquitinvinylsulfoneisapotent,irreversIBLeandspecificinhibitorofdeubiquitinatingenzymes(DUBs)basedonaC-terminalelectrophilicvinylsulfonegroup.UbiquitinvinylsulfonecanbeusedforactivityprofilingexperimentsanddeterminingDUBinhibitorspecificity.IttargetsthreeofthefourmajorDUBfamilies:UCH(UbiquitinC-terminalhydrolases),USP(Ubiquitinspecificproteases),OTU(Ovariantumorproteases)andMJD(Machado-Josephindomainproteases)whileJAMMmetalloproteasesarenotinhibited.

Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。