首页 > Adipogen > Adipogen/Fraction II Degradation Kit (HeLa)/AG-44T-0111-KI01/1 Kit

提醒：代购产品，无质量问题不接受退换货，下单前请仔细核对信息。下单后请及时联系客服核对商品价格，订单生效后再付款。

Adipogen/Fraction II Degradation Kit (HeLa)/AG-44T-0111-KI01/1 Kit

价格：

登录查看

自营商城

解放采购

正品保障

及时交付

厂家直采

一站服务

货号：

AG-44T-0111-KI01

品牌：

Adipogen

会员服务：

尊享会员价

贵宾专线

运费优惠

闪电退款

福利优惠

上门换新

友情提示

以上价格仅为参考，请联系客服询价。

免费咨询热线

4000-520-616

产品说明

Specifications&Handling:PropertiesCrossreactivityHumanKitContains250μlofFractionIIHeLa75μlof10XUbiquitinSolution50μlof10XEnergyRegenerationSolution(ERS)20μlofMG132(ProteasomeInhibitorControl)NOTE:Thiskitsuppliesenoughmaterialsfor10x50µlreactions.OtherProductDataUse:Thiskitcontainsreagentstoallowforthecontrolleddegradationofexogenouslyaddedorendogenouslycontainedsubstrateproteinsthroughtheubiquitinproteasomepathway(UPP).FractionIIistheproteinfractionofacellextractthatbindstoanionexchangeresin.ItcontainsE1,mostE2s,someE3s,UCHs,andtheproteasome(20Sand26S);andisessentiallyfreeofubiquitinandATP.OriginManufacturedbyBostonBiochemProductTypeKitShippingandHandlingShippingDRYICEShortTermStorage-20°CLongTermStorage-80°CHandlingAdviceAliquottoavoidfreeze/thawcycles.Use/StABIlityStableforatleast6monthsafterreceiptwhenstoredat-80°C.DocumentsManualDownloadDescription:Theubiquitinproteasomepathway(UPP)isthecell’sprinciplemechanismforproteincatabolism.TheUPPhasbeenshowntohavesignificantinvolvementintheregulationofcriticalcellularprocessessuchastranscription,oncogenesis,cellcycleprogression,development,growth,selectiveeliminationofabnormalproteinsandantigenprocessing.Theproteasomeisalarge,multimericproteasethatcatalyzesthefinalstepoftheUPPintracellularproteindegradation.Theproteasomeexistsinmultipleformswithintheeukaryoticcell,andcontainedinallisoformsisthecatalyticcoreknownasthe20SProteasome.The20Sproteasome(700kDa)isarrangedasfouraxiallystackedheptamericringswithtwoβ-subunitringssandwichedbetweentwoα-subunitrings.Themulticatalyticcentersarelocatedwithintheinternalcavityoftheβ-subunits.The26SProteasomeisdefinedbyhavingoneortwo19Sregulatorycapsonthe20Scoreparticle.Itisthe26SthatisresponsIBLefortherecognitionandsubsequentdegradationofpoly-ubiquitinatedproteinsintosmallerpolypeptides.ThisdegradationisubiquitinandATPdependentandwillnotbe26SProteasomemediatedunlessthetargetsubstrateisfirstubiquitinatedviatheconjugationcascade.

Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。