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Adipogen/IL-37 (human) ELISA Kit/AG-45A-0041YEK-KI01/96 wells
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Specifications&Handling:ProductDataSynonymsInterleukin-1FamilyMember7;IL-1F7;FIL1zeta;IL-1X;Interleukin-1Homolog4;IL-1H4;Interleukin-1zeta;IL-1zeta;IL-1RP1;IL1F7;FIL1Z,IL1H4,IL1RP1PropertiesApplicationSetQuantitativeELISASpecificityDetectshumanIL-37(monomericanddimericforms).Doesnotcross-reactwithhumanIL-33,IL-38,IL-6,IL-23,IL-24ormouseIL-33andIL-38.CrossreactivityHumanQuantity1x96wells2x96wells(TwinPlex)Sensitivity10pg/mlRange0.016to1ng/mlSampleTypePlasma,SerumAssayTypeSandwichDetectionTypeColorimetricProductTypeKitShippingandHandlingShippingBLUEICEShortTermStorage+4°CLongTermStorage+4°CHandlingAdviceAfterstandardreconstitution,preparealiquotsandstoreat-20°C.Avoidfreeze/thawcycles.Plateandreagentsshouldreachroomtemperaturebeforeuse.Use/StABIlity12monthsafterthedayofmanufacturing.SeeexpirydateonELISAKitbox.DocumentsManualDownloadMSDSDownloadRelatedProductsIL-37(aa46-218)(human)(rec.)(His)anti-IL-37(human),pAbDescription:IL-37(IL-1F7;IL-1H4)isanIL-1familymemberthatisexpressedonlyincertaintypesofhumanorgansandcellssuchasheart,thymus,testis,kidney,mononuclearcells(PBMCs)anddendriticcells.IL-37isaninhibitorofinnateimmunitywithanti-inflammatoryproperties.Itbindstotheinterleukin-18receptor(IL-18R)anditsco-receptorSIGIRR.IL-37issecretedasafull-lengthandasaprocessedformstartingfromaminoacidVal46.Itplaysanimportantroleasalinkbetweeninnateandadaptiveimmunityandactsasaninhibitorofautoimmunediseasesandtumorgrowth.IL-37alsoinhibitedLipopolysaccharide(LPS)-inducedimmunologicalreactionandLPS-inducedosteoclastformationandboneresorption.ArecentstudyindicatesthatIL-37proteinformsahead-to-headhomodimerandthisstructurelimitsitsbioactivity.Variantswithmutationsconvertingthecytokineintoamonomericformare13foldmoreactivethanthedimericIL-37.
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