首页 > Adipogen > Adipogen/MDM2/S5a (human) Ubiquitination Kit/AG-44T-0119-KI01/1 Kit

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Adipogen/MDM2/S5a (human) Ubiquitination Kit/AG-44T-0119-KI01/1 Kit

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AG-44T-0119-KI01

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Adipogen

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Specifications & Handling: Product Data Synonyms MDM2 Ubiquitin Ligase Kit - S5a Substrate; Properties Crossreactivity Human Kit Contains 30μl of 10X E1 Enzyme 30μl of 10X E2 Enzyme (UBE2D3) 30μl of 10X GST-MDM2 30μl of 10X His-S5a Control Substrate 30μl of 10X Ubiquitin Solution 50μl of 10X Reaction Buffer 30μl of 10X Mg-ATP Solution 100μl of α-S5a Primary antibody 1ml of 5X Loading Buffer NOTE: Kit contains reagents sufficient for 10 x 30μl reactions and 5 Western Blots (mini-gel format). Other Product Data Use: This kit is designed for in vitro Mdm2/HDM2-mediated ubiquitination of user-supplied substrates such as p53, β-Arrestin, and DYRK2. Ubiquitinated proteins can be used in downstream applications, or analyzed by Western blot using antibodies specific for the target protein. A control substrate, angiocidin and detection antibody are included in the kit. Origin Manufactured by Boston Biochem Product Type Kit Shipping and Handling Shipping DRY ICE Short Term Storage -20°C Long Term Storage -80°C Handling Advice Aliquot to avoid freeze/thaw cycles. Use/Stability Stable for at least 6 months after receipt when stored at -80°C. Documents Manual Download Description:MDM2 is a key regulator of p53 tumor suppressor protein activity and stability. MDM2 binds to and inhibits the transactivation domain of p53. In addition, MDM2 controls p53 stability by functioning as its E3 ligase in ubiquitination and by shuttling p53 from the nucleus to the cytoplasm for subsequent degradation. The importance of the p53/MDM2 relationship is underscored by the existence of an autoregulatory feedback loop whereby activated p53 transcriptionally upregulates the expression of its own inhibitor, MDM2.

Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。