首页 > Adipogen > Adipogen/anti-α-Tubulin (acetylated), mAb (TEU318)/AG-20B-0068-C100/100 µg

提醒：代购产品，无质量问题不接受退换货，下单前请仔细核对信息。下单后请及时联系客服核对商品价格，订单生效后再付款。

Adipogen/anti-α-Tubulin (acetylated), mAb (TEU318)/AG-20B-0068-C100/100 µg

价格：

登录查看

自营商城

解放采购

正品保障

及时交付

厂家直采

一站服务

货号：

AG-20B-0068-C100

品牌：

Adipogen

会员服务：

尊享会员价

贵宾专线

运费优惠

闪电退款

福利优惠

上门换新

友情提示

以上价格仅为参考，请联系客服询价。

免费咨询热线

4000-520-616

产品说明

MoreInformationProductDetailsProductTypeMonoclonalAntibodyPropertiesCloneTEU318IsotypeMouseIgG1Source/HostPurifiedfromconcentratedhybridomatissueculturesupernatant.Immunogen/AntigenTubulinoftheCiliateEuploteselutedfromthe55kDabandofSDSgel.ApplicationWesternBlot: 1:2000ICC:1:2000CrossreactivityAllSpecificityDetectsK40acetylationofα-tubulin;signalspecificallyincreasedbymodificationwithtubulinacetyltransferaseα-TAT1.Purity≥95%(SDS-PAGE)PurityDetailProteinG-affinitypurified.Concentration1mg/mlFormulationLiquid.InPBScontaining10%glyceroland0.02%sodiumazide.ShippingandHandlingShippingBLUEICEShortTermStorage+4°CLongTermStorage-20°CHandlingAdviceAfteropening,preparealiquotsandstoreat-20°C.Avoidfreeze/thawcycles.Use/StABIlityStableforatleast1yearafterreceiptwhenstoredat-20°C.DocumentsMSDSDownloadPDFProductSpecificationSheetDatasheetDownloadPDFMicrotubulesarekeyelementsoftheeukaryoticCytoskeletonthatdynamicallyassemblefromheterodimersofα-andβ-tubulin.Twodifferentmechanismscangeneratemicrotubulediversity:theexpressionofdifferentα-andβ-tubulingenes,referredtoastubulinisotypes,andthegenerationofposttranslationalmodifications(PTMs)onα-andβ-tubulin.TubulinPTMsincludethewell-knownacetylationorphosphorylation,andothersthathavesofarmostlybeenfoundontubulin,detyrosination/tyrosination,polyglutamylationandpolyglycylation.ThesePTMsmighthaveevolvedtospecificallyregulatetubulinandmicrotubulefunctions.TubulinacetylationwasdiscoveredonK40offlagellarα-tubulininChlamydomonasreinhardtiiandisgenerallyenrichedonstablemicrotubulesincells.Itislocatedonthemicrotubulelumenalsurface.Asaresultofitslocalizationattheinnerfaceofmicrotubules,K40acetylationmightratheraffectthebindingofmicrotubuleinnerproteins,apoorlycharacterizedfamilyofproteins.FunctionalexperimentsincellshavefurthersuggestedthatK40acetylationregulatesintracellulartransportbyregulatingthetrafficofkinesinmotorsprobablybyindirectmechanisms.Acetyltransferaseα-Tat1(orMec-17)specificallyacetylateα-tubulinK40.Acetylationoftubulinbyα-Tat1accumulatesselectivelyinstable,long-livedmicrotubulesthusexplainingthelinkbetweenthisposttranslationalmodicationandstablemicrotubulesincells.However,thedirectcellularfunctionofK40acetylationonmicrotubulesisstillunclear.ProductReferencesIsolationandcharacterizationoflibrariesofmonoclonalantibodiesdirectedagainstvariousformsoftubulininParamecium:A.M.Callen,etal.;Biol.Cell81,95(1994)WhereandwhenismicrotubulediversitygeneratedinParamecium?Immunologicalpropertiesofmicrotubularnetworksintheinterphaseanddividingcells:A.Fleury,etal.;Protoplasma189,37(1995)StructuralinheritanceinParamecium:ultrastructuralevidenceforbasalbodyandassociatedrootletspolaritytransmissionthroughbinaryfission:F.Iftode&A.Fleury-Aubusson;Biol.Cell95,39(2003)Investigatingtubulinposttranslationalmodificationswithspecificantibodies:M.M.Magiera&C.Janke;InMethodsCellBiol.(Burlington:AcademicPress)115,247(2013)

Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。