首页 > Adipogen > Adipogen/anti-α1-Antitrypsin, mAb (48D2)/YIF-LF-MA0175/100 µl

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Adipogen/anti-α1-Antitrypsin, mAb (48D2)/YIF-LF-MA0175/100 µl

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YIF-LF-MA0175

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Adipogen

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4000-520-616

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MoreInformationProductDetailsSynonymsAAT;PRO0684;SERPINA1ProductTypeMonoclonalAntibodyPropertiesClone48D2IsotypeMouseIgG1κImmunogen/AntigenProteinpurifiedfromhumanplasma.ApplicationWesternBlot(1:4,000)IHC-PCrossreactivityHumanPurityDetailAmmoniumsulfateprecipitation.FormulationLiquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol.OtherProductDataClickhereforOriginalManufacturerProductDatasheetOurproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.DeclarationManufacturedbyAbFrontierShippingandHandlingShippingBLUEICEShortTermStorage+4°CLongTermStorage-20°CUse/StABIlityStableforatleast1yearafterreceiptwhenstoredat-20°C.DocumentsMSDSNoProductSpecificationSheetDatasheetDownloadPDFα1-antitrypsin,52kDa,istheprototypicmemberoftheserineproteaseinhibitor(serpin)superfamily,whichhaveamajorroleininactivatingneutrophilelastaseandotherproteasestomaintainprotease-antiproteasebalance.Theproteinissynthesizedmainlyintheliver,butexertsitsmainfunctioninthelungwhereitinhibitsavarietyofserineproteases,butprimarilyneutrophilelastase.Itprovidesmorethan90%oftheantiproteolyticshieldofthelowerrespiratorytractprotectingtheelastictissuefromdegradation.Disordersoftheenzymeincludeα1-antitrypsindeficiency,ahereditarydisorderinwhichlackofα1-antitrypsinleadstouninhibitedtissuebreakdownduringinflammation.Thiscausespulmonaryemphysemaandleadstolivercirrhosisinseverecases.Inhibitorofserineproteases.Itsprimarytargetiselastase,butitalsohasamoderateaffinityforplasminandthrombin.IrreversIBLyinhibitstrypsin,chymotrypsinandplasminogenactivator.Theaberrantforminhibitsinsulin-inducedNOsynthesisinplatelets,decreasescoagulationtimeandhasproteolyticactivityagainstinsulinandplasmin.ShortpeptidefromAAT(SPAAT)isareversiblechymotrypsininhibitor.Italsoinhibitselastase,butnottrypsin.Itsmajorphysiologicalfunctionistheprotectionofthelowerrespiratorytractagainstproteolyticdestructionbyhumanleukocyteelastase(HLE).ProductReferences1)AbusriwilH,StockleyRA.CurrOpinPulmMed.(2006)vol.12(2):p.125-31.(General)2)StollerJK,AboussouanLS.Lancet.(2005)vol.365(9478):p.2225-36.(General)3)RanesJ,StollerJK.SeminRespirCritCareMed.(2005)vol.26(2):p.154-66.(General)4)BrantlyM.AmJRespirCellMolBiol.(2002)vol.27(6):p.652-4.(General)

Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。