首页 > Adipogen > Adipogen/anti-α2-Macroglobulin, mAb (9A3)/YIF-LF-MA0138/100 µl

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Adipogen/anti-α2-Macroglobulin, mAb (9A3)/YIF-LF-MA0138/100 µl

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YIF-LF-MA0138

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Adipogen

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MoreInformationProductDetailsSynonymsA2M;CPAMD5;FWP007;α-2-M;α-2-Macroglobulin;C3andPZP-likeα-2-MacroglobulinDomain-containingProtein5ProductTypeMonoclonalAntibodyPropertiesClone9A3IsotypeMouseIgG2bκImmunogen/Antigenα2-macroglobulinproteinpurifiedfromhumanplasma.ApplicationELISAImmunoprecipitation(1μg)CrossreactivityHumanPurityDetailAmmoniumsulfateprecipitation.FormulationLiquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol.OtherProductDataClickhereforOriginalManufacturerProductDatasheetOurproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.DeclarationManufacturedbyAbFrontierShippingandHandlingShippingBLUEICEShortTermStorage+4°CLongTermStorage-20°CUse/StABIlityStableforatleast1yearafterreceiptwhenstoredat-20°C.DocumentsMSDSNoProductSpecificationSheetDatasheetDownloadPDFα2-Macroglobulin(α2M),isa720-kDahomotetramericglycoproteincomposedoffouridentical180kDasubunit.α2Mshareswithotherα-macroglobulins,likethecomplementcomponentsC3andC4andthepregnancyzoneproteinPZP,anextraordinarybindingcapacityforavarietyofligands.Thisallowstheα-macroglobulinstoserveashumoraldefensebarriersagainstforeignpeptidesintheplasma.α2Minteractsandcapturesvirtuallyanyproteinase,oftenreferredtoasapanproteaseinhibitor.InthebrainofAlzheimer"sdisease(AD)patients,α2Malsohasbeenlocalizedtodiffuseamyloidplaques,supportinganimportantroleforα2MinADetiopathology.Isabletoinhibitallfourclassesofproteinasesbyaunique"trapping"mechanism.Thisproteinhasapeptidestretch,calledthe"baitregion"whichcontainsspecificcleavagesitesfordifferentproteinases.Whenaproteinasecleavesthebaitregion,aconformationalchangeisinducedintheproteinwhichtrapstheproteinase.Theentrappedenzymeremainsactiveagainstlowmolecularweightsubstrates(activityagainsthighmolecularweightsubstratesisgreatlyreduced).Followingcleavageinthebaitregionathioesterbondishydrolyzedandmediatesthecovalentbindingoftheproteintotheproteinase.ProductReferences1)Borth,W(1992)FASEB.J.6(15):3345-3353.(General)2)TravisJetal(1983)Annu.Rev.Biochem.52:655-709.(General)

Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。