首页 > Adipogen > Adipogen/anti-β-Catenin (C-term), pAb/YIF-LF-PA0162/100 µl

提醒：代购产品，无质量问题不接受退换货，下单前请仔细核对信息。下单后请及时联系客服核对商品价格，订单生效后再付款。

Adipogen/anti-β-Catenin (C-term), pAb/YIF-LF-PA0162/100 µl

价格：

登录查看

自营商城

解放采购

正品保障

及时交付

厂家直采

一站服务

货号：

YIF-LF-PA0162

品牌：

Adipogen

会员服务：

尊享会员价

贵宾专线

运费优惠

闪电退款

福利优惠

上门换新

友情提示

以上价格仅为参考，请联系客服询价。

免费咨询热线

4000-520-616

产品说明

MoreInformationProductDetailsSynonymsCTNNB;CTNNB1;β-Catenin;Cateninβ-1ProductTypePolyclonalAntibodyPropertiesImmunogen/AntigenRecombinanthumanHis-β-Catenin(C-terminalfragment)proteinpurifiedfromE.coli.ApplicationWesternBlot(1:2,000)Immunoprecipitation(1~2μl)CrossreactivityHumanMouseRatFormulationLiquid.HEPESwith0.15MNaCl,0.01%BSA,0.03%sodiumazide,and50%glycerol.OtherProductDataClickhereforOriginalManufacturerProductDatasheetOurproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet.DeclarationManufacturedbyAbFrontierShippingandHandlingShippingBLUEICEShortTermStorage+4°CLongTermStorage-20°CUse/StABIlityStableforatleast1yearafterreceiptwhenstoredat-20°C.DocumentsMSDSNoProductSpecificationSheetDatasheetDownloadPDFβ-Cateninwasacytosolicproteinoriginallyidentifiedthroughitsassociationwiththecadherinclassofcell-adhesionproteins.β-Cateninhastwokeycellularfunctions;oneplaysdirectroleincelladhesion/migration,bridgingbetweencadherinsandtactinCytoskeleton.TheotherplaysasatranscriptioncofactorwithTcellfactor/lymphoidenhancerfactor(TCF/LEF)intheWntpathway.Wntarepowerfulregulatorsofcellproliferationanddifferentiation,andtheirsignalingpathwayinvolvesproteinsthatdirectlyparticipateinbothgenetranscriptionandcelladhesion.ActivationofWntsignalingleadstoinhibitionofGlycogensynthase-3β(GSK-3β)activity,resultinginaccumulationofcytoplasmic(signaling)β-Catenin,whichbecomesavailabletobindtheTCF/LEFfamilyoftranscriptionfactorsandtoinducetargetgeneexpression.IntheabsenceofWntsignaling,Acomplexofaxinandcaseinkinase-I(CK-I)inducesβ-Cateninphospho-rylationatasinglesite:serine45(Ser45).ThislikelyservesasaprimingsiteforsubsequentphosphorylationbyGSK3β.Andthenβ-CateninisphosphorylatedbyGSK-3βatSer33/37andThr41.Theseserine/threoninephosphylationisrequiredforthephosphrylation-dependantdegradationofβcateninviaubiquitin-proteosomepathway.Mutationofthesephosphorylationsitesinβ-Cateninhasbeenfoundinmanytumorcelllines.InvolvedintheregulationofcelladhesionandinsignaltransductionthroughtheWntpathway.ProductReferences1)HinckL,etal.(1994)TrendsBiochemSci.19(12):538-42.(General)2)SchneiderSQ,etal.(2003)JExpZoologBMolDevEvol.295(1):25-44.(General)3)W.JamesNelsonetal.(2004)Science303:1483-7.(General)4)AmitS,etal.(2002)GenesDev.16(9):1066-76.(General)(5)MorinP.J.,etal.(1997)Science275:1787-1790.(General)

Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。