More Information Product Details Synonyms GQ1b . 4Na; Tetrasialoganglioside GQ1b . 4Na Product Type Chemical Properties Formula C106H178N6O55 . 4Na MW 2416.6 . 92.0 (calculated on sphingosine C18:1 and stearic acid) Sequence Structure: IV3Neu5Ac2II3NeuAc2GgOse4Cer; α-Neu5Ac-(2-8)-α-Neu5Ac-(2-3)-β-Gal-(1-3)-β-GalNAc-(1-4)-[α-Neu5Ac-(2-8)-α-Neu5Ac-(2-3)-]β-Gal-(1-4)-β-Glc-(1-1)-Cer; Cer: Sphingosine C18:1-C20:1, ~1:1 by vol.; stearic acid over 90% CAS 68652-37-9 Source/Host Chemicals Isolated from bovine brain. Purity Chemicals ≥98% (TLC) Solubility Soluble in water (micellar aggregates) or chloroform:methanol (2:1). Formulation Lyophilized. Endotoxin Content Not detectable. Identity Determined by 1H-NMR, MS and HPTLC. InChi Key QISNAVHLOKDTLS-UTKQHEHRSA-J Shipping and Handling Shipping AMBIENT Short Term Storage +4°C Long Term Storage -20°C Handling Advice Hygroscopic.Protect from moisture. Use/Stability Stable for at least 2 years after receipt when stored at -20°C. Documents MSDS Download PDF Product Specification Sheet Datasheet Download PDF Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GQ1b specifically promotes neural differentiation of human neuroblastoma cells. Anti-GQ1b antibodies are present in serum from Miller-Fisher syndrome patients. Product References Role of membrane gangliosides in the binding and action of bacterial toxins: P.H. Fishman; J. Membr. Biol. 69, 85 (1982) A novel glycosignaling system: GQ1b-dependent neuritogenesis of human neuroblastoma cell line, GOTO, is closely associated with GQ1b-dependent ecto-type protein phosphorylation. S. Tsuji, et al.; Neurochem. 21, 549 (1992) Dynamic and structural properties of sphingolipids as driving force to the formation of membrane domains: S. Sonnino, et al.; Chem. Rev. 106, 2111 (2006) Fisher syndrome: clinical features, immunopathogenesis and management. M. Mori, et al.; Expert Rev. Neurother. 12, 39 (2012)