SpecificationsDescriptionEndothelin receptor type B (EDNRB) is expressed in most tissues. Mutations in this receptor are responsible for Hirschsprung disease type 2, a multigenic disorder with phenotypes such as bicolored irides, megacolon, hypopigmentation, and hearing loss. EDNRB has similar affinity for all three endothelins and activates a phosphatidylinositol-calcium second messenger system. A splice variant, termed SVR, has been described; the sequence of the ETB-SVR receptor is identical to ET-B receptor, with the exception of the intracellular C-terminal domain. While both splice variants bind endothelin ET1, they exhibit different responses, which suggests that they may be functionally distinct.References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804(2) Publication(s)TargetHuman EDNRB / Endothelin B ReceptorSynonymsEDNRB | ABCDS | Endothelin B receptor | Etb receptor | ET-B | Et-b receptor | Et-b-r | ET-RB | ETBR | ETRB | Etb-svr | WS4A | Endothelin receptor type B | ET-BR | ETB | HSCR | HSCR2 See All EDNRB / Endothelin B Receptor AntibodiesHostRabbitReactivityHuman, Dog(tested or 100% immunogen sequence identity)ClonalityPolyclonalConjugationsUnconjugated.Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.PurificationImmunoaffinity purifiedModificationsUnmodifiedImmunogenSynthetic 19 amino acid peptide from N-Terminus extracellular domain of human EDNRB. Percent identity with other species by BLAST analysis: Human, Dog (100%); Gorilla, Gibbon (95%); Monkey (89%); Marmoset (84%).EpitopeN-TerminusSpecificityHuman EDNRB. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except PTPN5 (68%).ApplicationsIHCIHC - Paraffin (4 - 11 µg/ml)ICCWestern blotPerforming IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agentsABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.PresentationPBS, 0.1% Sodium AzideStorageAliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.RestrictionsFor research use only. Intended for use by laboratory professionals.GuaranteeThis antibody carries the LSBio 100% Guarantee.LSBio GuaranteeAbout EDNRB / Endothelin B ReceptorUniprot:P24530NCBI:NM_000115NP_000106.1