SpecificationsDescriptionLTB4R2 is a low-affinity receptor for leukotrienes including leukotriene B4. It mediates the chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3. LTB4R2 has been found to be overexpressed in esophageal squamous cell cancer and may be involved in the early stages of carcinogenesis. In immunohistochemistry, LTB4R2 has membranous positivity in the spleen, thymus, tonsil, and lymph nodes, and is found on lymphocytes, macrophages, and potentially neutrophils. It is also present on neuronal subsets in the caudate nucleus, globus pallidus, subiculum, hippocampus, amygdala and tuberal nucleus within the central nervous system. It is positive in a wide range of cancers, including glioblastoma, breast cancer, colorectal adenocarcinoma, pulmonary adenocarcinoma, Hodgkin's disease, ovarian cancer, pancreatic cancer and lamignant melanoma.References: BMC Gastroenterol 16, 85 (2016), doi:10.1186/s12876-016-0499-z(2) Publication(s)TargetHuman LTB4R2 / BLT2SynonymsLTB4R2 | BLT2 | BLTR2 | Blt-2 | BLT2R | JULF2 | LTB4-R2 | Hblt2 | KPG_004 | Leukotriene B4 receptor 2 | Leukotriene B4 receptor BLT2 | LTB4 receptor JULF2 | LTB4-R 2 See All LTB4R2 / BLT2 AntibodiesHostRabbitReactivityHuman, Monkey(tested or 100% immunogen sequence identity)ClonalityPolyclonalConjugationsUnconjugatedPurificationImmunoaffinity purifiedModificationsUnmodifiedImmunogenSynthetic 16 amino acid peptide from 3rd cytoplasmic domain of human LTB4R2. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset (100%); Mouse, Rat, Bat (88%); Elephant (81%).EpitopeCytoplasmic DomainSpecificityHuman LTB4R2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.ApplicationsIHCIHC - Paraffin (26 µg/ml)IHC - FrozenFlow CytometryPerforming IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agentsABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.PresentationPBS, 0.1% Sodium AzideStorageAliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.RestrictionsFor research use only. Intended for use by laboratory professionals.GuaranteeThis antibody carries the LSBio 100% Guarantee.LSBio GuaranteeAbout LTB4R2 / BLT2Uniprot:Q9NPC1NCBI:NM_019839NP_062813.2