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Lifespan/PathPlus™ GLP1R / GLP‑1 Receptor Antibody N‑Terminus Polyclonal IF,IHC,WB LS‑A1205/50 µg (1 mg/ml)/LS-A1205-50
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DescriptionGlucagon-likepeptide1receptor(GLP1R)isareceptorforglucagonandglucagon-likepeptide-1(GLP1).Itisinvolvedininsulinsynthesisandrelease,bloodglucosehomeostasis,appetitecontrol,memoryandlearning,aswellascontrolofbreathingandheartrate.StimulationofGLP1Rbyendogenoushormoneinducesmultiplecomplementarymechanisms,whichtogetherresultinaloweringofcirculatingbloodglucoselevels.DesensitizationofGLP1Ronpancreaticbeta-cellsisoneofthecausesofnoninsulin-dependentdiabetesmellitus(NIDDM).Inimmunohistochemistry,GLP1Rhashighestmembranouspositivityonpancreaticbetacells,itisexpressedonneuronsinthebrainandnervoussystem,anditisalsofoundinthestomach,salivarygland,heartmuscle,gallbladder,salivarygland,duodenumandatlowlevelsinafewothertissues.TheUniProtConsortium.NucleicAcidsRes.47:D506-515(2019);NucleicAcidsRes.2016Jan4;44(D1):D733-45,PMID:26553804(8)Publication(s)TargetHumanGLP1R/GLP-1ReceptorSeeAllGLP1R/GLP-1ReceptorAntibodiesHostRabbitReactivityHuman,Mouse(testedor100%immunogensequenceidentity)ClonalityPolyclonalConjugationsUnconjugated.AlsoavailableconjugatedwithAP,APC,Biotin,FITC,HRP,PE.PurificationImmunoaffinitypurifiedModificationsUnmodifiedApplicationsIHCIHC-Paraffin(15-20µg/ml)ImmunofluorescenceWesternblotApplicationstestedforthebaseformofthisproductonlyPerformingIHC?SeeourcompletelineofImmunohistochemistryReagentsincludingantigenretrievalsolutions,blockingagentsABCDetectionKitsandpolymers,biotinylatedsecondaryantibodies,substratesandmore.ImmunogenSynthetic16aminoacidpeptidefromN-TerminusextracellulardomainofhumanGLP1R.PercentidentitywithotherspeciesbyBLASTanalysis:Human,Gorilla,Gibbon,Monkey(100%);Mouse,Bovine,Hamster,Elephant,Rabbit,Pig(94%);Rat,Dog,Bat,Panda(88%).BlockingPeptideLS-E35682-Liquid-50µg1mg/ml-$145.00ImmunizingpeptideusedtogenerateLS-A1205.Usefulforpre-absorptionandneutralizationoftheantibody'santigenbindingsite.EpitopeN-TerminusSpecificityHumanGLP1R.BLASTanalysisofthepeptideimmunogenshowednohomologywithotherhumanproteins,exceptRUSC2(44%).PresentationPBS,0.1%SodiumAzideStorageAliquotandstoreundilutedat-20°Corbelowforupto1year.Canbestoredundilutedat4°Cforupto1month.Avoidfreeze-thawcycles.RestrictionsForresearchuseonly.GuaranteeThisantibodycarriestheLSBIo100%Guarantee.LSBioGuaranteeAboutGLP1R/GLP-1ReceptorUniprot:P43220NCBI:NM_002062NP_002053.3
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