Human IFN Alpha Sampler SetHome / Products / Proteins / Interferons / Human IFN Proteins / Human IFN Alpha Sampler SetProduct Features:Contains 12 distinct human IFN alpha subtypes for differential activity studiescDNAs of interferons were obtained from human leukocyte mRNA, and expressed in E.coliProvides 100,000 units of IFNa-A, IFNa-B2, IFNa-C, IFNa-D (1[Val114]), IFNa-F, IFNa-G, IFNa-H2, IFNa-I, IFNa-J1, IFNa-K, IFNa-4b, and IFNa-WA (corresponding to IFNa-2a, IFNa-8, IFNa-10, IFNa-1, IFNa-21, IFNa-5, IFNa-14, IFNa-17, IFNa-7, IFNa-6, IFNa-4b, IFNa-16, respectively) OrderingCatalog No. Pack Size Price Quantity 11002-1 1 x 105 units$2,195.00 SpecificationsTech Info / DataCitationsDocumentationSpecificationsFormulationIndividual interferons are supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)Molecular Weight19.2 -19.7 kDaSourcecDNA of interferons were obtained from human leukocyte mRNA, and expressed in E.coliPurity> 95% by SDS-PAGE stained by Coomassie BlueBioactivityActivities of the interferons are measured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV)StorageFor retention of full activity store at -70 ºC or below and avoid repeated freeze-thaw cyclesSynonymsInterferon alpha subtypes, IFN alpha subtypes, IFN-a subtypes, interferon alpha, Leukocyte interferon subtypes, Leukocyte IFN subtypes, alpha interferon subtypes, interferon alfa subtypes, IFN alfa, interferon a, Type I interferon alpha, Type I IFN alpha, Human interferon alpha, IFN-alpha, INF alpha, Human IFN alpha 2a, human IFN alpha 8, human IFN alpha 10, human IFN alpha 1, human IFN alpha 21, human IFN alpha 5, human IFN alpha 14, human IFN alpha 17, human IFN alpha 7, human IFN alpha 6, human IFN alpha 4b, human IFN alpha 16Accession NumberRefer to CoA Tech Info / DataBackground:The Human IFN Alpha Sampler Set provides a collection of 12 distinct biologically active alpha interferons which enables studies of their activity in various applications.The Human interferon alpha protein family consists of 12 individual protein species, each with reported different biological properties. Some have proven to be 10 and 20 times more effective than Human IFN-alpha A in protecting a cell against specific viruses. Elucidating the functional significances of various IFN-alpha subtypes not only can lead to a better understanding on the role interferons have in an immunological event, but can also lead to the refinement of current interferon based therapeutic applications.Human IFN Alpha Subtype NomenclatureGeneIFN Alpha AIFN Alpha 2aIFNA2IFN Alpha 2IFN Alpha 2bIFNA2IFN Alpha B2IFN Alpha 8IFNA8IFN Alpha CIFN Alpha 10IFNA10IFN Alpha D [Val114]IFN Alpha 1IFNA1IFN Alpha FIFN Alpha 21IFNA21IFN Alpha GIFN Alpha 5IFNA5IFN Alpha H2IFN Alpha 14IFNA14IFN Alpha IIFN Alpha 17IFNA17IFN Alpha J1IFN Alpha 7IFNA7IFN Alpha KIFN Alpha 6IFNA6IFN Alpha 1 [Ala114]IFN Alpha DIFNA1IFN Alpha 4aIFN Alpha M1IFNA4IFN Alpha 4bIFN Alpha 4IFNA4IFN Alpha WAIFN Alpha 16IFNA16For more information on Human IFN Alpha subtype molecular weight, and theoretical pI click here. Citations9 Citations:Prevost, Jeremie, et al. (2019). Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses. mBio, 18 pgs. PMID: 31213558. (link)Schlaepfer, et al. (2019). Dose-Dependent Differences in HIV Inhibition by Different Interferon Alpha Subtypes While Having Overall Similar Biologic Effects. mSphere, 14 pgs. PMID: 30760614. (link)Cook, Bradley, et al. (2016). Limited Effects of Type I Interferons on Kyasanur Forest Disease Virus in Cell Culture. PLOS Neglected Tropical Diseases, 19 pgs. PMID: 27479197. (link)Lavender, Kerry, et al. (2016). Interferon Alpha Subtype-Specific Suppression of HIV-1 Infection in Vivo. JVI, 13 pgs. PMID: 27099312. (link)Todt, Daniel, et al. (2016). Antiviral Activities of Different Interferon Types and Subtypes Against Hepatitis E Virus Replication. Antimicrobial Agents and Chemotherapy, 8 pgs. PMID: 26787701. (link)Harper, Michael, et al. (2015). Interferon-alpha Subtypes in an Ex Vivo Model of Acute HIV-1 Infection: Expression, Potency, and Effector Mechanisms. PLOS Pathogens, 24 pgs. PMID: 26529416. (link)Schanen, C, et al. (2006). Correlation Between the Anti-Viral-Induced Cytopathic Effect of Interferon-alpha Subtypes and Induction of MxA Protein In Vitro. Microbiology and Immunology, 19 pgs. PMID: 16428869. (link)Francois, Catherine, et al. (2005). Quantification of Different Human Alpha Interferon Subtypes and Pegylated Interferon Activities by Measuring MxA Promoter Activation. Antimicrobial Agents and Chemotherapy, 6 pgs. PMID: 16127052. (link)Sperber, Steven, et al. (1992). Anti-HIV-1 activity of recombinant and hybrid species of interferon-alpha. Journal of Interferon Research, 6 pgs. PMID: 1331260. (link)References:For more information on the various alleles of IFN alpha 2a, 2b, 4a, 4b, 1 and D.Gewart, DR., et al. (1995). J Interferon Cytokine Res. 15 (5):403Hussain, M., et al. (1997). J Interferon Cytokine Res. 17 (9):559Hussain, M., et al. (2000). J Interferon Cytokine Res. 20:763 Documentation 11002-1 Certificate of Analysis (CoA) SDS