首页 > GloboZymes > GloboZymes/Anti-AK/PAK2/100μl-200μg/GLO151-100

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GloboZymes/Anti-AK/PAK2/100μl-200μg/GLO151-100

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GLO151-100

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Anti-AK/PAK2GloboZymes Anti-AK/PAK2 is an affinity-purified polyclonal antibody produced in rabbits to a synthetic peptide corresponding to residues 273-291 of the catalytic domain of human lymphocyte PAK2. The antibody is useful for Western blotting. For example, it can be used at 1:1000 dilution with 20 μg HEK293 cell extracts. The antibody reacts with PAK2 and its catalytic domain from diverse tissue sources.Synonyms: Polyclonal Antibody to Auto-Activated Protein Kinase; Autophosphorylation-Activated Protein Kinase; Catalytic Domain of PAK2; Catalytic Domain of p21-Activated Protein Kinase.Background: The catalytic domain of PAK2 (AK/PAK2) was originally isolated as an auto-activated protein kinase (AK). Thus, the purified enzyme underwent rapid autophosphorylation and concomitant 15-30-fold activation. Subsequent discovery of the PAK family of enzymes and amino sequencing of AK revealed that AK was equivalent to the catalytic domain of PAK2. Unlike native PAK2, AK does not require p21-GTPases Cdc42 and Rac for expression of its activity. Interestingly, AK is a physiologically relevant form of PAK2. It is produced from the native enzyme via a caspase-dependent pathway in cells undergoing apoptosis.Figure: Purified preparations of AK/PAK2 were subjected to Western Blot with GloboZymes affinity-purified rabbit polyclonal antibody Anti-AK/PAK2. The band correspond to AK/PAK2 (~ 36 kDa).References: Proc Natl Acad Sci USA 90: 2500; J Biol Chem 268: 11193; J Cell Physiol 178: 397; J Biol Chem 276: 14909

GloboZymesDEK蛋白

来源：在大肠杆菌中生产的带有GST标签的重组人肾脏。

纯度：通过SDS-PAGE＞ 90％，表观先生〜70-kDa。

提供：在50μl50 mM Tris-HCl pH 7.0缓冲液中1μg，该缓冲液包含14 mMβ-巯基乙醇，1 mM苯甲idine，0.1 mM苯基甲磺酰氟，1 mM EDTA和10％甘油。将制剂分装在-70°C下。避免反复融化。

别名：DEK-GST癌蛋白

背景：DEK是一种明显的Mr〜43 kDa的核磷酸蛋白，由于急性髓性白血病和骨髓增生异常综合症的一部分发生复发性（6; 9）染色体易位，与核孔蛋白CAN融合。DEK还可以在青少年类风湿关节炎和其他风湿性疾病中充当自身免疫抗原。DEK与转录共抑制子Human Daxx，SRm160剪接共激活子和HIV-2增强子相关。它通过将约束的正超螺旋引入无蛋白和染色质相关的DNA中来改变DNA的拓扑。DEK与I2PP2A / SET具有某些结构相似性，在急性未分化白血病中也与CAN融合蛋白出现。但是，DEK确实会直接影响PP2A的活性。