首页 > GloboZymes > GloboZymes/eIF4E(S209A)/30μg/GLO119-030

提醒：代购产品，无质量问题不接受退换货，下单前请仔细核对信息。下单后请及时联系客服核对商品价格，订单生效后再付款。

GloboZymes/eIF4E(S209A)/30μg/GLO119-030

价格：

登录查看

自营商城

解放采购

正品保障

及时交付

厂家直采

一站服务

货号：

GLO119-030

品牌：

GloboZymes

会员服务：

尊享会员价

贵宾专线

运费优惠

闪电退款

福利优惠

上门换新

友情提示

以上价格仅为参考，请联系客服询价。

免费咨询热线

4000-520-616

产品说明

eIF4E(S209A)Source: Recombinant human produced in E. coliPurity: > 90% by SDS-PAGE, apparent Mr ~ 28-kDaSupplied: In 50 μl of 50 mM Tris-HCl pH 7.0 buffer containing 14 mM β-mercaptoethanol, 1 mM benzamidine, 0.1 mM phenylmethanesulfonyl fluoride, 1 mM EDTA and 10% glycerol. Maintain in aliquots at -70° C. Avoid repeated thawing.Synonyms: Eukaryotic Protein Synthesis Initiation Factor 4E Phosphorylation Site Mutant (Serine 209 to Alanine); eIF-4E(S209A).Background: The mRNA Cap-binding protein synthesis initiation factor 4E (eIF4E) participates in an early rate limiting step in protein synthesis. Over-expression of eIF4E leads to cell transformation and tumorigenesis and occurs in a number of cancer cells. In quiescent cells, eIF4E occurs as an inactive complex with the 4EBP binding proteins. In response to insulin and other extracellular stimuli, eIF4E dissociates from 4EBP and is recruited to the active eIF4F complex. The active eIF4F complex contains eIF4A and eIF4G in addition to eIF4E. In response to insulin and other growth factors, eIF4E is phosphorylated at Ser209. This phosphorylation enhances the affinity of eIF4E to capped mRNA. It is catalyzed by Mitogen-Activated Protein Kinase (MAPK) Interacting Kinases (Mnk’s). It is also catalyzed by an insulin-stimulated kinase termed cPK which also phosphorylates Thr210 on the initiation factor. Figure: SDS-PAGE pattern of a purified preparation of eIF4E(S209A). The gel was stained with Coomassie Blue.References: J Biol Chem 270, 14824-14828; J Biol Chem 270, 14597-14603; Biochime 76, 822-830; J Biol Chem 271, 11831-11837; J Biol Chem 270, 21684-21688

GloboZymesDEK蛋白

来源：在大肠杆菌中生产的带有GST标签的重组人肾脏。

纯度：通过SDS-PAGE＞ 90％，表观先生〜70-kDa。

提供：在50μl50 mM Tris-HCl pH 7.0缓冲液中1μg，该缓冲液包含14 mMβ-巯基乙醇，1 mM苯甲idine，0.1 mM苯基甲磺酰氟，1 mM EDTA和10％甘油。将制剂分装在-70°C下。避免反复融化。

别名：DEK-GST癌蛋白

背景：DEK是一种明显的Mr〜43 kDa的核磷酸蛋白，由于急性髓性白血病和骨髓增生异常综合症的一部分发生复发性（6; 9）染色体易位，与核孔蛋白CAN融合。DEK还可以在青少年类风湿关节炎和其他风湿性疾病中充当自身免疫抗原。DEK与转录共抑制子Human Daxx，SRm160剪接共激活子和HIV-2增强子相关。它通过将约束的正超螺旋引入无蛋白和染色质相关的DNA中来改变DNA的拓扑。DEK与I2PP2A / SET具有某些结构相似性，在急性未分化白血病中也与CAN融合蛋白出现。但是，DEK确实会直接影响PP2A的活性。