OverviewData/SpecificationsLiterature/SupportHow To UseRelated ProductsOverviewOverview:Type III collagen is the second most abundant collagen in tissues and is found most commonly in tissues exhibiting elastic properties such as skin, lungs, intestinal walls and walls of blood vessels. It is a homotrimer comprised of three alpha-1 chains and resembles other fibrillar collagens in structure and function. It is synthesized as procollagen, similary to collagen I, but the N-terminal propeptide remains attached in the mature fibrillar type III form.Mutations of type III collagen causes Ehlers-Danlos syndrome, EDS IV, which affect arteries, internal organs, joints and skin, and may cause sudden death when the large arteries rupture.Symbols/Related Terms:COL3A1Collagen type III, alpha 1Collagen III, alpha-1 polypeptidecollagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant)EDS4AData/SpecificationsData/Specifications:Purity:Bovine collagen type III - 90%Other bovine collagens - 10%Non-collagen proteins - below 0.5%Form: 10 mg lyophilized, salt-freeSource: Bovine (calf ) skin. Collagen was extracted from washed dissected tissue into dilute acetic acid after pepsin treatment. Collagen type III was purified by using differential salt precipitation.Purification: Partial pepsin digestion in acidic conditions and differential salt precipitation.Reconstitution: Use 0.5 M acetic acid, pH 2.5. Dissolved collagen retains immunologic properties of native collagen. Structure of native collagen confirmed by ability to form microfibrils.Storage:Collagen dissolved in acetic acid is stable at 4 °C for 1 month. Lyophilized collagen long term storage (2 years) at -20°C or lower.Literature/SupportLiterature/Support/Publications:Bovine Type III Collagen Insert (PDF)Note: inserts are for review only. Please refer to the insert shipped with your product to ensure the most up-to-date revision is being used.How To UseHow To Use:Key Applicatons:Used for rat collagen type I standard.Antigen for antibody production.Coating material for cell culture studies.Collagen microfibrils will activate platelets causing aggregation.Note: May not be suitable for 3-D gel formation.Related ProductsRelated Products:Citrullinated Collagen Type II Antibody (Clone ACC-1)Citrullinated Collagen Type II Antibody (Clone ACC-4)Collagen Type I and III, BovineCollagen Type I and III, canineCollagen Type I and III, mouseCollagen Type I and III, PorcineCollagen Type I and III, RatCollagen Type I Antibody, anti-mouseCollagen Type I Antibody, anti-ratCollagen Type I, BovineCollagen Type I, GoatCollagen Type I, MouseCollagen Type I, RatCollagen Type II Antibody, anti-humanCollagen Type II, Bovine, LyophilizedCollagen Type II, Bovine, SolubleCollagen Type II, Chicken, LyophilizedCollagen Type II, Chicken, SolubleCollagen Type II, Rat LathyriticCollagen Type II, Rat LathyriticCollagen Type II, Rat Pepsin DigestedCollagen Type II, Rat Pepsin-DigestedCollagen Type IV Antibody, anti-mouse Incomplete Freund's AdjuvantReverse Related Products:Collagen Type III (Atelocollagen) Bovine