SpecificationGene InfoPathwayDiseaseRelated ProductsList AllSpecificationProduct Description:Mouse monoclonal antibody raised against human CD45RA.Immunogen:Fresh human lymph node lymphocytes depleted of surface immunoglobulin positive cells.Host:MouseTheoretical MW (kDa):220Reactivity:HumanForm:LiquidConjugation:APCPurification:Protein A/G purificationPurity:>90%Isotype:IgG2b, kappaRecommend Usage:Flow Cytometry (20 uL/106 cells)ImmunofluorescenceImmunohistochemistry (Frozen sections)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)The optimal working dilution should be determined by the end user.Storage Buffer:In PBS, pH 7.4 (protein stabilizer, 0.09% sodium azide).Storage Instruction:Store in the dark at 4°C.Note:This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.Datasheet:DownloadApplicationsImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)Immunohistochemistry (Frozen sections)ImmunofluorescenceFlow CytometryFlow cytometric analysis of human peripheral blood lymphocytes with CD45RA monoclonal antibody, clone HI100 (APC) (Cat # MAB13677).Application ImageImmunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)Immunohistochemistry (Frozen sections)ImmunofluorescenceFlow CytometryenlargeGene InformationEntrez GeneID:5788Protein Accession#:P08575Gene Name:PTPRCGene Alias:B220,CD45,CD45R,GP180,LCA,LY5,T200Gene Description:protein tyrosine phosphatase, receptor type, COmim ID:126200, 151460, 609532Gene Ontology:HyperlinkGene Summary:The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeqOther Designations:CD45 antigen,T200 glycoprotein,T200 leukocyte common antigen,glycoprotein,leukocyte-common antigen,protein tyrosine phosphatase, receptor type, c polypeptideGene PathwayCell adhesion molecules (CAMs)Fc gamma R-mediated phagocytosisPrimary immunodeficiencyT cell receptor signaling pathwayRelated Disease Arthritis, Juvenile Rheumatoid Arthritis, Rheumatoid Ascariasis Autoimmune Diseases Cardiomyopathy, Dilated Diabetes Mellitus, Type 1 Genetic Predisposition to Disease Graves Disease Hashimoto Disease Hepatitis B Hepatitis C Hepatitis, Autoimmune HIV Infections Inflammatory Bowel Diseases Lupus Erythematosus, Systemic Lymphopenia Multiple Sclerosis Paraparesis, Tropical Spastic Scleroderma, Systemic ... see more Severe Combined Immunodeficiency Severe combined immunodeficiency Thyroiditis, Autoimmune ... hiddenRelated ProductDH0044 CD45 monoclonal antibody (PE)DH0072 CD45 monoclonal antibody (Alexa 647)DH0081 CD45 monoclonal antibodyDH0090 CD45 monoclonal antibody PLUS (PE)H00005788-M12 PTPRC monoclonal antibody (M12), clone 3D3H00005788-Q01 PTPRC (Human) Recombinant Protein (Q01)H00005788-Q02 PTPRC (Human) Recombinant Protein (Q02)H00005788-W01P PTPRC DNAxPabMAB0886 PTPRC monoclonal antibody, clone MEM-28MAB0887 PTPRC monoclonal antibody, clone MEM-56MAB0888 PTPRC monoclonal antibody, clone MEM-55MAB10539 PTPRC monoclonal antibody, clone 4A8A4C7A2MAB1108 PTPRC monoclonal antibody, clone 3G4MAB11298 PTPRC monoclonal antibody, clone 2B11MAB11299 CD45RA monoclonal antibody, clone 158-4D3MAB11300 CD45RO monoclonal antibody, clone UCHL-1MAB11484 PTPRC monoclonal antibody, clone PD7-26MAB12049 PTPRC monoclonal antibody, clone SPM125MAB12050 PTPRC monoclonal antibody, clone SPM568MAB12051 PTPRC monoclonal antibody, clone SPM570MAB12052 PTPRC monoclonal antibody, clone SPM569MAB12142 PTPRC monoclonal antibody, clone BRA-11MAB12143 PTPRC monoclonal antibody, clone BRA-11 (AF488)MAB12144 PTPRC monoclonal antibody, clone BRA-11 (PE)MAB12226 PTPRC monoclonal antibody, clone HIT30 (FITC)MAB12230 CD45RA monoclonal antibody, clone HI100 (FITC)MAB12231 CD45RO monoclonal antibody, clone UCHL1 (FITC)MAB12403 PTPRC monoclonal antibody, clone 4AA9MAB12404 PTPRC monoclonal antibody, clone 4AA9 (FITC)MAB12405 PTPRC monoclonal antibody, clone 4AA9 (PE)MAB12406 PTPRC monoclonal antibody, clone 4AA9 (PE-Cy5)MAB12407 PTPRC monoclonal antibody, clone 4AA9 (APC)MAB12408 PTPRC monoclonal antibody, clone 4AA9 (Biotin)MAB12634 PTPRC monoclonal antibody, clone PD7/26/16 + 2B11MAB12737 PTPRC monoclonal antibody, clone YTH24.5MAB13023 CD45RA monoclonal antibody, clone PTPRC/1131MAB13024 CD45RB monoclonal antibody, clone PTPRC/1132MAB13025 CD45RB monoclonal antibody, clone PTPRC/1147MAB13026 CD45RA monoclonal antibody, clone PTPRC/1148MAB13027 CD45RA monoclonal antibody, clone PTPRC/818MAB13149 CD45RA monoclonal antibody, clone SPM504MAB13150 CD45RA monoclonal antibody, clone SPM504MAB13405 PTPRC monoclonal antibody, clone 136-4B5MAB13406 PTPRC monoclonal antibody, clone 136-4B5MAB13407 CD45RB monoclonal antibody, clone DF-B1MAB13408 CD45RB monoclonal antibody, clone DF-B1MAB13409 CD45RO monoclonal antibody, clone T200/797MAB13410 CD45RO monoclonal antibody, clone T200/797MAB13411 CD45RA monoclonal antibody, clone 111-1C5MAB13412 CD45RA monoclonal antibody, clone 111-1C5MAB13413 PTPRC monoclonal antibody, clone 135-4C5MAB13414 PTPRC monoclonal antibody, clone 135-4C5MAB13678 CD45RA monoclonal antibody, clone HI100 (PerCP)MAB13679 CD45RA monoclonal antibody, clone HI100 (Biotin)MAB13680 CD45RA monoclonal antibody, clone HI100 (CF-Blue)MAB13681 CD45RB monoclonal antibody, clone MC5/2 (PE)MAB13682 CD45RB monoclonal antibody, clone MC5/2 (APC)MAB13683 CD45RB monoclonal antibody, clone MC5/2 (CF-Blue)MAB13684 CD45RC monoclonal antibody, clone RP1/12 (FITC)MAB13685 CD45RC monoclonal antibody, clone RP1/12 (PE)MAB13686 CD45RC monoclonal antibody, clone RP1/12 (APC)MAB13928 PTPRC monoclonal antibody, clone D3/9 (FITC)MAB13929 PTPRC monoclonal antibody, clone D3/9 (PE)MAB13930 PTPRC monoclonal antibody, clone D3/9 (APC)MAB13931 PTPRC monoclonal antibody, clone D3/9 (PerCP)MAB13932 PTPRC monoclonal antibody, clone D3/9 (DY-634)MAB13933 PTPRC monoclonal antibody, clone D3/9 (Biotin)MAB13934 PTPRC monoclonal antibody, clone D3/9 (CF-Blue)MAB13936 PTPRC monoclonal antibody, clone HI30MAB13937 PTPRC monoclonal antibody, clone HI30 (PE)MAB13938 PTPRC monoclonal antibody, clone HI30 (APC)MAB13939 PTPRC monoclonal antibody, clone HI30 (PerCP)MAB13940 PTPRC monoclonal antibody, clone HI30 (Biotin)MAB13941 PTPRC monoclonal antibody, clone HI30 (CF-Blue)MAB13942 PTPRC monoclonal antibody, clone HI30 (OC-515)MAB13943 PTPRC monoclonal antibody, clone HI30 (APC-C750)MAB13944 CD45RA monoclonal antibody, clone GRT22 (FITC)MAB13945 CD45RA monoclonal antibody, clone GRT22 (CF-Blue)MAB13946 CD45RA monoclonal antibody, clone HI100 (PE)MAB14693 CD45RO monoclonal antibody, clone UCHL-1+T200/797MAB14694 CD45RO monoclonal antibody, clone UCHL-1+T200/797MAB14695 PTPRC monoclonal antibody, clone PTPRC/1460MAB14696 PTPRC monoclonal antibody, clone PTPRC/1460MAB14697 PTPRC monoclonal antibody, clone PTPRC/1461MAB14698 PTPRC monoclonal antibody, clone PTPRC/1461MAB15208 PTPRC monoclonal antibody, clone SPM569 + SPM570MAB15209 PTPRC monoclonal antibody, clone SPM569 + SPM570MAB15544 PTPRC monoclonal antibody, clone CL0159MAB15545 PTPRC monoclonal antibody, clone CL0160MAB15935 PTPRC monoclonal antibody, clone E19-GMAB16148 PTPRC monoclonal antibody, clone F10-89-4 (FITC)MAB16165 CD45RA monoclonal antibody, clone MB1MAB16251 CD45RO monoclonal antibody, clone UCHL1MAB1649 PTPRC monoclonal antibody, clone E19-GMAB16595 PTPRC monoclonal antibody, clone 2C10C11MAB16914 PTPRC monoclonal antibody, clone RM291MAB19841 PTPRC monoclonal antibody, clone CBI-16MAB3508 PTPRC monoclonal antibody, clone 2B11/PD7/26MAB3874 PTPRC monoclonal antibody, clone MEM-143MAB4145 PTPRC monoclonal antibody, clone 289-11241MAB4434 PTPRC monoclonal antibody, clone UCHL1 (APC)MAB4436 PTPRC monoclonal antibody, clone UCHL1 (PE)MAB4575 PTPRC monoclonal antibody, clone MEM-28 (APC)MAB4578 PTPRC monoclonal antibody, clone MEM-28 (Biotin)MAB4583 PTPRC monoclonal antibody, clone MEM-28 (FITC)MAB4586 PTPRC monoclonal antibody, clone MEM-28 (PE)MAB4590 PTPRC monoclonal antibody, clone MEM-28 (PerCP)MAB4624 CD45RA monoclonal antibody, clone MEM-56 (APC)MAB4625 CD45RA monoclonal antibody, clone MEM-56 (Biotin)MAB4626 CD45RA monoclonal antibody, clone MEM-56 (FITC)MAB4627 CD45RA monoclonal antibody, clone MEM-56 (PE)MAB4629 CD45RB monoclonal antibody, clone MEM-55 (APC)MAB4631 CD45RB monoclonal antibody, clone MEM-55 (FITC)MAB4632 CD45RB monoclonal antibody, clone MEM-55 (PE)MAB4982 PTPRC monoclonal antibody, clone D3/9MAB4983 CD45RA monoclonal antibody, clone GRT22MAB4984 CD45RB monoclonal antibody, clone MC5/2MAB4985 CD45RC monoclonal antibody, clone RP1/12MAB5305 PTPRC monoclonal antibody, clone BRA-55MAB5626 PTPRC monoclonal antibody, clone F10-89-4MAB6064 PTPRC monoclonal antibody, clone F10-89-4 (FITC)MAB6066 PTPRC monoclonal antibody, clone F10-89-4 (PE)MAB6067 PTPRC monoclonal antibody, clone F10-89-4 (APC)MAB6068 PTPRC monoclonal antibody, clone F10-89-4 (SPRD)MAB6069 PTPRC monoclonal antibody, clone F10-89-4 (Cy5)MAB6070 PTPRC monoclonal antibody, clone F10-89-4 (PE/Cy5.5)MAB6071 PTPRC monoclonal antibody, clone F10-89-4 (PE/Cy7)MAB6491 PTPRC monoclonal antibody, clone MEM-56 (PerCP)MAB6953 CD45RA monoclonal antibody, clone 158.4D3MAB6954 CD45R monoclonal antibody, clone 351C5MAB6955 PTPRC monoclonal antibody, clone C11PAB30255 PTPRC polyclonal antibodyPAB3629 PTPRC polyclonal antibodyRAB00349 CD45RB recombinant monoclonal antibody, clone PTPRC/1783RRAB00350 CD45RB recombinant monoclonal antibody, clone PTPRC/1783RRAB00613 PTPRC recombinant monoclonal antibody, clone PTPRC/1975RRAB00614 PTPRC recombinant monoclonal antibody, clone PTPRC/1783R + PTPRC/1975RRAB00615 PTPRC recombinant monoclonal antibody, clone PTPRC/2877R