首页 > Millipore > Millipore/15-203 | Alzheimers Disease II - Amyloidosis Investigator Antibody Mini-Pack/15-203/3 vials/Pk

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Millipore/15-203 | Alzheimers Disease II - Amyloidosis Investigator Antibody Mini-Pack/15-203/3 vials/Pk

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15-203

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DescriptionCatalogueNumber15-203TradeNameUpstateDescriptionAlzheimer"sDiseaseII-AmyloidosisInvestigatorAntibodyMini-PackBackgroundInformationPathwayInvestigatorAntibodyMiniPack:EachPathwayExplorerAntibodyMinipackcontainsthreerelatedantibodiesaspartofasignalingcascadeoracombinationoftotalandphosphorylatedformsofkeysignalingtargets.Eachofthethreeantibodiesare30%theoriginalpacksize.FullsizeversionsofeachofthePathwayExplorerantibodiesareavailableforsaleindividuallyunderthesamecatalognumberwiththeremovalof“SP”offofeachone(e.g.05-591SPcanbeorderedas05-591).AlzheimerPrecursorProteinA4,clone22C11:DepositsofamyloidproteininsenileplaquesnearnerveprocessesarefoundinthebrainsofagedhumandandcasesofAlzheimer"sDisease.Theprinciplecomponentofthisextracellularamyloidisbeta/A4,a4kDapeptidederivedfromalargeramyloidprecursorprotein(APP),whichiswidelyexpressedinthebrainandbody.Thecreation,transportandfunctionoftheseproteinsarecurrentlyunderinvestigation.14-3-3-eC-Terminus:Mammalsexpresssevendistinct14-3-3isoforms(gamma,epsilon,beta,zeta,sigma,theta,tau)thatformmultiplehomo-andhetero-dimmers,thusrendering14-3-3asakeymultifunctionalregulatorymolecule.14-3-3isomershavebeenimplicatedinseveralneurologicaldisorders:forexampleisoformsgamma,epsilonandbetaareexpressedinthecerebrospinalfluidofCreutzfeldt-Jakobpatients,butnotpatientssufferingfromotherneurologicalconditionssuchasAlzheimer"s.The14-3-3epsilon,C-terminalantibodyisoneofapanelofantibodiesthatweregeneratedagainst14-3-3isoformsandhavedemonstratedtheirpotentialforuseasanELISA-baseddiagnostictool.TheseantibodieswillallowtheresearchtoinvestigatetheroleofthisproteininkeycellularprocessesandneurologicaldisorderssuchasCreutzfeldt-Jakob,Alzheimer"sandParkinson"sDisease.*Seefullsizeversionsforcorrespondingreferences.ProductInformationComponentsMAB348SP-Anti-AmyloidPrecursorProtein,cloneA4;15ugAB9732SP-Anti-14-3-3-eC-terminus;30uLAB9890SP-Anti-AGE;60uLPresentation3individualtubescontainingeitherAnti-AlzheimerPrecursorProteinA4,clone22C11;Anti-14-3-3epsilon,C-terminal;orAnti-AGE(AdvancedGlycationEnd-products)PropertiesEachvialis30%thesizeoftheparentcatalognumberStorageandShippingInformationApplicationsApplicationAlzheimer"sDiseaseII-AmyloidosisInvestigatorAntibodyMini-Pack.BIOLOGicalInformationCrossReactivityVaries.SeeindividualDataSheetsEntrezGeneNumberNM_000484.2NM_201413.1NM_201414.1NM_006761.3GeneSymbolAPPPN-IIAD1ABETACTFgammaAPPIABPPA4CVAPPN2PreA4AAAYWHAEKCIP-1MDS14-3-3EMDCRFLJ45465UniProtNumberP05067P62258UniProtSummaryFUNCTION:SwissProt:P62258#Adapterproteinimplicatedintheregulationofalargespectrumofbothgeneralandspecializedsignalingpathway.Bindstoalargenumberofpartners,usuallybyrecognitionofaphosphoserineorphosphothreoninemotif.Bindinggenerallyresultsinthemodulationoftheactivityofthebindingpartner.SIZE:255aminoacids;29174DaSUBUNIT:Homodimer.InteractswithNDEL1(Bysimilarity).InteractswithHCVcoreprotein.SUBCELLULARLOCATION:Cytoplasm(Bysimilarity).Melanosome.Note=IdentifiedbymassspectrometryinmelanosomefractionsfromstageItostageIV.SIMILARITY:SwissProt:P62258##Belongstothe14-3-3family.PhysicochemicalInformationDimensionsMaterialsInformationMaterialsInformation

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为了更好地满足中国用户的需求，密理博中国主页于2006年11月向广大用户开放，介绍密理博中国有限公司的最新动态，力求为用户打造专业的产品与服务信息交流平台。