首页 > Millipore > Millipore/MABN381 | Anti-APP-C99 Antibody, clone mC99(1-7)/MABN381/100 µL

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Millipore/MABN381 | Anti-APP-C99 Antibody, clone mC99(1-7)/MABN381/100 µL

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DescriptionCatalogueNumberMABN381DescriptionAnti-APP-C99Antibody,clonemC99(1-7)AlternateNamesAmyloidbetaA4proteinABPPAPPIAPPAlzheimerdiseaseamyloidproteinCerebralvascularamyloidpeptideCVAPPreA4Proteasenexin-IIPN-IIBackgroundInformationAmyloidPrecursorProtein(APP)isexpressedinthebrain,kidney,heart,andspleenoffetaltissues;itisinducedduringneuronaldifferentiation.Themost-substantiatedroleforAPPisinsynapticformationandrepair;itsexpressionisupregulatedduringneuronaldifferentiationandafterneuralinjury.Inadultbrain,highestexpressionofAPPisfoundinthefrontallobeofthecortex.Moderateexpressionisobservedinthecerebellarcortex,theposteriorperisylviancortex-operculargyriandthetemporalassociatedcortex.DefectsinAPPareacauseofautosomaldominantAlzheimer"sdisease(AD).UPonintracerebroventricularinjectionofthisantibody,AbetalevelssignificantlydecreasedinthebrainofAPPPS1mousemodelofAD.Arelatedantibody,Cat.No.MABN380,Anti-APP-C99,clonemC99(70-80)wasraisedagainstaslightlydifferentregionofthesameAPP-C99protein.ProductInformationFormatAscitesPresentationMousemonoclonalIgGκinascitescontaining0.05%sodiumazide.StorageandShippingInformationStorageConditionsStablefor1yearat-20°Cfromdateofreceipt.HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.ApplicationsApplicationAnti-APP-C99Antibody,clonemC99(1-7)isahighlyspecificmousemonoclonalantibody,thattargetsAPP&hasbeentestedinwesternblotting,IP,ICC&IHC.KeyApplicationsWesternBlottingImmunoprecipitationImmunocytochemistryImmunohistochemistryApplicationNotesImmunoprecipitationAnalysis:ArepresentativelotimmunoprecipitatedAPP-C99inHEKAPPSwecelllysate(Houacine,J.,etal.(2012).NeurobiolAging.33(11):2704-2714.).ImmunohistochemistryAnalysis:ArepresentativelotdetectedAPP-C99inAPPS1miceandinhumanAlzheimerbraintissues(Houacine,J.,etal.(2012).NeurobiolAging.33(11):2704-2714.).ImmunofluoresenceAnlaysis:ArepresentativelotdetectedAPP-C99inHEKAPPSwecells(Houacine,J.,etal.(2012).NeurobiolAging.33(11):2704-2714.).BIOLOGicalInformationImmunogenRecombinantproteincorrespondingtoHumanAPP-C99.ClonemC99(1-7)HostMouseSpeciesReactivityHumanMouseAntibodyTypeMonoclonalAntibodyEntrezGeneNumberNP_000475GeneSymbolAPPA4AD1PurificationMethodUnpurifiedUniProtNumberP05067MolecularWeight~95kDaobserved.Uncharacterizedband(s)maybeobservedinsomecelllysates.PhysicochemicalInformationDimensionsMaterialsInformationMaterialsInformation

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