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Millipore/NS145 | Dopaminergic Neuron Integration and Characterization Kit/NS145/1 kit
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DescriptionCatalogueNumberNS145BrandFamilyChemicon®TradeNameChemiconDescriptionDopaminergicNeuronIntegrationandCharacterizationKitOverviewSeeindividualdatasheetsforspecificcomponentdescriptions.BackgroundInformationDopaminergicneurondysfunctionandlosscorrelateswithnumerousprogressiveanddevastatingneurologicaldiseases.Stemcellresearchandapplicationsarerapidlymovingtowardtheintroductionandsubsequentpost-developmentanalysisofembryonicstem(ES)cell-deriveddopaminergicneuronsinadulttissue.TheNS145ispartofanexpandingChemicon/UpstateproductlinetargetingdevelopmentandplasticityinneuroBIOLOGy.NS145isanovel,broadlyencompassingkitforthelocalization,characterizationandanalysisofEScellderiveddopaminergicneuronintegrationintoadultcentralnervoussystem(CNS)tissue.Thiskitallowsresearchersto:(1)identifyandcharacterizedopaminergicneuronsintissue;and(2)identifyotherneighboringneuronaltypesandastrocytes.Inaddition,theantibodiesareamixtureofmouseandratmonoclonalsandrABItandgoatpolyclonalstooptimizedouble,triple,andquadruplestainingparADIgms.Thekitcomponentbreakdownisasfollows:(1)Identifyingdopaminergicneurons.ResearchersareinterestedinidentifyingthesubtypeofneuronthattheirtaggedEShavematuredintofollowingintroductionandintegrationintotherecipientCNS.Thisisakeystepindopaminergicneuronreplacementtherapy.ThiskitincludesantibodiesfortheidentificationofdopaminergicneuronsusingseveraldiverseMarkerstargetingdifferentstagesintheneurotransmittersynthesisandmaintainance:DopaDecarboxylase(AB1569-50UL);TyrosineHydroxylase(TH;MAB5280-20UG);DopamineTransporter(DAT;MAB369-50UL).(2)Identifyotherneuronalsubtypesandastrocytesneighboringthetransplantedcells.InordertomeasurethelevelofstructuralintegrationofthetaggedEScells,researchersoftenusegeneralmarkersofneuronalsubtypeandastrocytestocharacterizethelocalenvironmentinwhichtheEScell-deriveddopaminergicneuronsareintegrating.Thekitincludesantibodiesforthegeneralidentificationofneurons(NeuN;MAB377-100UG)andastrocytes(GFAP;AB5804).Alsoincludedareexcellentmarkersfortheidentificationofcholinergic(ChAT;AB144P-200UL)andSEROtonergic(Serotonin;MAB352-50UL)neurons.Additional,individualreagentscanbeorderedseparatelyinlargerquantities.ProductInformationComponentsOnekitcontainingthefollowingcomponents:100μgofNeuNmousemonoclonalMAB377-100UG50μLofDopaDecarboxylaserabbitpolyclonalAB1569-50UL50μLofDATratmonoclonalMAB369-50UL50μLofGFAPrabbitpolyclonalAB5804200μLofChATgoatpolyclonalAB144P-200UL50μLofSerotoninratmonoclonalMAB352-50UL20μgofTyrosineHydroxylasemousemonoclonalMAB5280-20UGStorageandShippingInformationStorageConditionsMaintaincomponentsaccordingtotheindividualdatasheets.ImportantNote:Duringshipment,smallvolumesofproductwilloccasionallybecomeentrappedinthesealoftheproductvial.Forproductswithvolumesof200μLorless,werecommendgentlytappingthevialonahardsurfaceorbrieflycentrifugingthevialinatable-topcentrifugetodislodgeanyliquidinthecontainer"scap.ApplicationsKeyApplicationsImmunohistochemistryImmunocytochemistryBiologicalInformationSpeciesReactivityVertebratesEntrezGeneNumberNM_000790.3NM_001082971.1EntrezGeneSummaryThedopaminetransporter(DAT1)mediatestheactivereuptakeofdopaminefromthesynapseandisaprincipalregulatorofdopaminergicneurotransmission.TheDAT1genehasbeenimplicatedinhumandisorderssuchasparkinsonism,Tourettesyndrome,andsubstanceabuse(Vandenberghetal.,1992[PubMed1359373]).[suppliedbyOMIM]GeneSymbolDDCAADCEC4.1.1.28UniProtNumberP20711Q01959P14136P28329P07101UniProtSummaryFUNCTION:SwissProt:Q01959#Aminetransporter.Terminatestheactionofdopaminebyitshighaffinitysodium-dependentreuptakeintopresynapticterminals.SIZE:620aminoacids;68495DaSUBUNIT:Homooligomer;disulfide-linked.InteractswithPRKCABPandTGFB1I1.SUBCELLULARLOCATION:Membrane;Multi-passmembraneprotein.SIMILARITY:SwissProt:Q01959##Belongstothesodium:neurotransmittersymporter(SNF)family.MISCELLANEOUS:Thisproteinisthetargetofpsychomotorstimulantssuchasamphetaminesorcocaine.PhysicochemicalInformationDimensionsMaterialsInformationMaterialsInformation

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