首页 > Millipore > Millipore/06-1310 | Anti-JAK2 Antibody/06-1310/100 µg

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Millipore/06-1310 | Anti-JAK2 Antibody/06-1310/100 µg

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DescriptionCatalogueNumber06-1310DescriptionAnti-JAK2AntibodyAlternateNamesJanuskinase2Januskinase2(aproteintyrosinekinase)tyrosine-proteinkinaseJAK2BackgroundInformationTheJanusfamilyoftyrosinekinases(JAK)includesJAK1,JAK2,JAK3andTyk2.Thisfamilyassociateswithavarietyofcytokinereceptorsandisactivatedbyligandbinding.Uponligandbindingtocytokinereceptors,JAKsphosphorylatethemselvesandtheirassociatedreceptors.ThisprovidesmultiplebindingsitesforsignalingproteinscontainingSH2orotherphospho-tyrosine-bindingdomains,includingSTATs,Shc,insulinreceptorsubstratesandFAK.ProductInformationFormatPurifiedControlRAW264.7celllysatePresentationPurifiedrabbitpolyclonalinbuffercontaining0.1MTris-Glycine(pH7.4,150mMNaCl)with0.05%sodiumazide.StorageandShippingInformationStorageConditionsStablefor1yearat2-8°Cfromdateofreceipt.ApplicationsApplicationThisAnti-JAK2AntibodyisvalidatedforuseinWB,IPforthedetectionofJAK2.KeyApplicationsWesternBlottingImmunoprecipitationApplicationNotesWesternBlotAnalysis:1µg/mLfromapreviouslotdetectedJAK2in10µgofL6celllysate.ImmunoprecipitationAnalysis:10µgfromapreviouslotimmunoprecipitatedJAK2fromRAW264.7celllysate.BIOLOGicalInformationImmunogenKLH-conjugatedlinearpeptidecorrespondingtotheproteinkinase1domainofmouseJAK2.EpitopeProteinkinase1domainConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.HostRabbitSpecificityThisantibodyrecognizestheproteinkinase1domainofJAK2.SpeciesReactivityMouseHumanRatMouseAntibodyTypePolyclonalAntibodyEntrezGeneNumberNP_001041642GeneSymbolJAK2JAK-2PurificationMethodProteinAPurfiedUniProtNumberQ62120UniProtSummaryFUNCTION:Tyrosinekinaseofthenon-receptortype,involvedininterleukin-3andprobablyinterleukin-23signaltransduction(Bysimilarity).Playsaroleinleptinsignalingandcontrolofbodyweight.CATALYTICACTIVITY:ATP+a[protein]-L-tyrosine=ADP+a[protein]-L-tyrosinephosphate.SUBUNITSTRUCTURE:InteractswithIL23R,SKB1andSTAM2(Bysimilarity).InteractswithSIRPAandSH2B1.SUBCELLULARLOCATION:Endomembranesystem;PeripheralmembraneproteinBysimilarity.Note:Whollyintracellular,possIBLymembraneassociated(Bysimilarity).DOMAIN:Possessestwophosphotransferasedomains.Thesecondoneprobablycontainsthecatalyticdomain(Bysimilarity),whilethepresenceofslightdifferencessuggestadifferentrolefordomain1.PTM:Leptinpromotesphosphorylationontyrosineresidues,includingphosphorylationonTyr-813.SEQUENCESIMILARITIES:Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.JAKsubfamily.Contains1FERMdomain.Contains1proteinkinasedomain.Contains1SH2domain.MolecularWeight~130kDaPhysicochemicalInformationDimensionsMaterialsInformationMaterialsInformation

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