首页 > Millipore > Millipore/AB9730 | Anti-14-3-3 β Antibody/AB9730/100 µL

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Millipore/AB9730 | Anti-14-3-3 β Antibody/AB9730/100 µL

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DescriptionCatalogueNumberAB9730Replaces04-1089BrandFamilyChemicon®TradeNameChemiconDescriptionAnti-14-3-3βAntibodyBackgroundInformationMammalsexpresssevendistinct14-3-3isoforms(gamma,epsilon,beta,zeta,sigma,theta,tau)thatformmultiplehomo-andhetero-dimmers,thusrendering14-3-3asakeymultifunctionalregulatorymolecule.14-3-3isomershavebeenimplicatedinseveralneurologicaldisorders:forexampleisoformsgamma,epsilonandbetaareexpressedinthecerebrospinalfluidofCreutzfeldt-Jakobpatients,butnotpatientssufferingfromotherneurologicalconditionssuchasAlzheimer"s.The14-3-3betaantibodyisoneofapanelofantibodiesthatweregeneratedagainst14-3-3isoformsandhavedemonstratedtheirpotentialforuseasanELISA-baseddiagnostictool.TheseantibodieswillallowtheresearchtoinvestigatetheroleofthisproteininkeycellularprocessesandneurologicaldisorderssuchasCreutzfeldt-Jakob,Alzheimer"sandParkinson"sDisease.ProductInformationFormatSerumPresentationLiquid.StorageandShippingInformationStorageConditionsMaintainat-20°Cinundilutedaliquotsforupto6monthsafterdateofreceipt.Avoidrepeatedfreeze/thawcycles.Duringshipment,smallvolumesofproductwilloccasionallybecomeentrappedinthesealoftheproductvial.Forproductswithvolumesof200µLorless,werecommendgentlytappingthevialonahardsurfaceorbrieflycentrifugingthevialinatabletopcentrifugetodislodgeanyliquidinthecontainer"scapApplicationsApplicationDetect14-3-3βusingthisAnti-14-3-3βAntibodyvalidatedforuseinELISA,WB,IH.KeyApplicationsELISAWesternBlottingImmunohistochemistryApplicationNotesWesternblot:1:3,000usingECLImmunohistochemistry:1:300-1:600onmousebraintissuewhichwastreatedbyhydratedautoclavingat121°Cfor15minutespriortoimmunolabeling.Endogenousperoxidasewasblockedwithhydrogenperoxideinmethanolandnon-specificlabelingwithnormalgoatserumat1:20for5minutes.ELISAOptimalworkingdilutionsmustbedeterminedbyenduser.BIOLOGicalInformationImmunogenSyntheticpeptidefromtheN-terminalareaofsheep14-3-3beta.HostRabbitSpecificity14-3-3beta.ByWesternblottheantibodyrecognizesthe~30kDaprotein.SpeciesReactivityBovineHumanMouseRatRabbitSheepAntibodyTypePolyclonalAntibodyEntrezGeneNumberNM_003404.3NM_139323.2EntrezGeneSummaryThisgeneencodesaproteinbelongingtothe14-3-3familyofproteins,membersofwhichmediatesignaltransductionbybindingtophosphoserine-containingproteins.Thishighlyconservedproteinfamilyisfoundinbothplantsandmammals.TheencodedproteinhasbeenshowntointeractwithRAF1andCDC25phosphatases,suggestingthatitmayplayaroleinlinkingmitogenicsignalingandthecellcyclemachinery.Twotranscriptvariants,whichencodethesameprotein,havebeenidentifiedforthisgene.GeneSymbolYWHABKCIP-1HS1GW128PurificationMethodSerumUniProtNumberP31946UniProtSummaryFUNCTION:SwissProt:P31946#Adapterproteinimplicatedintheregulationofalargespectrumofbothgeneralandspecializedsignalingpathway.Bindstoalargenumberofpartners,usuallybyrecognitionofaphosphoserineorphosphothreoninemotif.Bindinggenerallyresultsinthemodulationoftheactivityofthebindingpartner.SIZE:246aminoacids;28082DaSUBUNIT:Homodimer.InteractswithSSH1.SUBCELLULARLOCATION:Cytoplasm.Melanosome.Note=IdentifiedbymassspectrometryinmelanosomefractionsfromstageItostageIV.PTM:Isoformalphadiffersfromisoformbetainbeingphosphorylated(Bysimilarity).&IsoformShortcontainsaN-acetylmethionineatposition1(Bysimilarity).SIMILARITY:SwissProt:P31946##Belongstothe14-3-3family.MolecularWeight30kDaPhysicochemicalInformationDimensionsMaterialsInformationMaterialsInformation

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