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Millipore/AB1846 | Anti-C-X-C Chemokine Receptor 4 Antibody, NT/AB1846/100 µg
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DescriptionCatalogueNumberAB1846BrandFamilyChemicon®TradeNameChemiconDescriptionAnti-C-X-CChemokineReceptor4Antibody,NTAlternateNamesCD184CXCR4ProductInformationFormatPurifiedControlSkinPresentationPurifiedIgGinPBScontaining0.02%sodiumazide.StorageandShippingInformationStorageConditionsMaintain1yearat4°C,fromdateofshipment.Donotfreeze.Formaximumrecoveryofproduct,centrifugetheoriginalvialafterthawingandpriortoremovingthecap.ApplicationsApplicationAnti-C-X-CChemokineReceptor4Antibody,N-terminusisanantibodyagainstC-X-CChemokineReceptor4foruseinIC,IP&WB.KeyApplicationsImmunocytochemistryImmunoprecipitationWesternBlottingApplicationNotesWesternblot:1-2μg/mL.HeLacelllysatescanbeusedaspositivecontrol.Theantibodyshoulddetectabandat40kDa.Immunocytochemistry:10μg/mLImmunoprecipitationOptimalworkingdilutionsmustbedeterminedbyenduser.BIOLOGicalInformationImmunogenAmino-terminuspeptideofhumanCXCR4(Berson,1996;Leotscher,1994).EpitopeN-terminusConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.HostRabbitSpecificityRecognizesCXCR4,N-terminus.SpeciesReactivityHumanAntibodyTypePolyclonalAntibodyEntrezGeneNumberNM_001008540.1NM_003467.2EntrezGeneSummaryThisgeneencodesaCXCchemokinereceptorspecificforstromalcell-derivedfactor-1.Theproteinhas7transmembraneregionsandislocatedonthecellsurface.ItactswiththeCD4proteintosupportHIVentryintocellsandisalsohighlyexpressedinbreastcancercells.MutationsinthisgenehavebeenassociatedwithWHIM(warts,hypogammaglobulinemia,infections,andmyelokathexis)syndrome.Alternatetranscriptionalsplicevariants,encodingdifferentisoforms,havebeencharacterized.GeneSymbolCXCR4WHIMNPY3RNPYY3RFB22LAP3FusinCXCR-4LCR1NPYRHM89fusinHSY3RRCXC-R4NPYY3NPYRLD2S201ECD184LESTRPurificationMethodProteinAPurfiedUniProtNumberP61073UniProtSummaryFUNCTION:SwissProt:P61073#ReceptorfortheC-X-CchemokineCXCL12/SDF-1.Transducesasignalbyincreasingtheintracellularcalciumionslevel.Involvedinhaematopoiesisandincardiacventricularseptumformation.Playsalsoanessentialroleinvascularizationofthegastrointestinaltract,probablybyregulatingvascularbranchingand/orremodelingprocessesinendothelialcells.Couldbeinvolvedincerebellardevelopment.IntheCNS,couldmediatehippocampal-neuronsurvival.Actsasacoreceptor(CD4beingtheprimaryreceptor)forHIV-1X4isolatesandasaprimaryreceptorforsomeHIV-2isolates.PromotesEnv-mediatedfusionofthevirus.SIZE:352aminoacids;39746DaSUBUNIT:InteractswithHIV-1surfaceproteingp120andTat.SUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein.TISSUESPECIFICITY:Expressedinnumeroustissues,suchasperipheralbloodleukocytes,spleen,thymus,spinalcord,heart,placenta,lung,liver,skeletalmuscle,kidney,pancreas,cerebellum,cerebralcortexandmedulla(inmicrogliaaswellasinastrocytes),brainmicrovascular,coronaryarteryandumbilicalcordendothelialcells.Isoform1ispredominantinalltissuestested.DOMAIN:SwissProt:P61073Theamino-terminusiscriticalforligandbinding.ResiduesinallfourextracellularregionscontributetoHIV-1coreceptoractivity.PTM:Sulfated.DISEASE:SwissProt:P61073#DefectsinCXCR4areacauseofWHIMsyndrome[MIM:193670];alsocalledwarts,hypogammaglobulinemia,infections,andmyelokathexis.WHIMsyndromeisanimmunodeficiencydiseasecharacterizedbyneutropenia,hypogammaglobulinemiaandextensivehumanpapillomavirus(HPV)infection.Despitetheperipheralneutropenia,bonemarrowaspiratesfromaffectedindividualscontainabundantmaturemyeloidcells,aconditiontermedmyelokathexis.SIMILARITY:BelongstotheG-proteincoupledreceptor1family.MolecularWeight40kDaPhysicochemicalInformationDimensionsMaterialsInformationMaterialsInformation

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20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。

为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。