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DescriptionCatalogueNumberAB4250BrandFamilyChemicon®TradeNameChemiconDescriptionAnti-CXCChemokineReceptor3Antibody,CTdomainAlternateNamesCXCR3BackgroundInformationCXCR3,achemokinereceptor,ishighlysimilartotheinterleukin8BreceptorandhasbeenshowntomediaterecruitmentofTcellstositesofinflammationandretentionofT-cellsintheinflamedCNS.CXCR3hasbeensuggestedtobetheprincipalinflammatorychemokinereceptorinvolvedinintrathecalaccumulationofT-cellsinmultiplesclerosisanddiabetes.ItisexpressedonmalignantBcellsinchroniclymphoproliferativedisorders(Jonesetal.,2000).Analternativelysplicedisoform,CXCR3B,hasrecentlybeenidentified(Lasagnietal.,2003).CXCR3expressionhasbeendocumentedinthebrain,lymphoidandotherperipheraltissues,andindiseasesincludingatherosclerosis,Alzheimer"s,multiplesclerosis,rheumatoidarthritis,lymphomas,asthma,neoplasms,leukemia,andinflammatoryconditionsofvariousorgans.ProductInformationFormatAffinityPurifiedPresentationPeptide-affinitypurifiedimmunoglobulin.Liquidinphosphatebufferedsaline,pH7.7,containing0.01%sodiumazideStorageandShippingInformationStorageConditionsMaintainat-70°Cinundilutedaliquotsforupto12monthsfromdateofreceipt.Maybestoredat2-8°Cforshorttermuse.Avoidrepeatedfreeze/thawcycles.ApplicationsApplicationAnti-CXCChemokineReceptor3Antibody,C-terminaldomaindetectslevelofCXCChemokineReceptor3&hasbeenpublished&validatedforuseinIH(P).KeyApplicationsImmunohistochemistry(Paraffin)ApplicationNotesImmunohistochemistry(formalin-fixedparaffin-embeddedtissues)Optimalworkingdilutionsmustbedeterminedbytheenduser.BIOLOGicalInformationImmunogenSyntheticpeptidecorrespondingtoasequencewithintheC-terminaldomainofhumanCXCR3.Theimmunogenhas82%homologywithratandmouse.EpitopeC-terminaldomainConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.HostRabbitSpecificityRecognizeshumanCXCR3.ThespecificityofthisantibodyhasbeenevaluatedbyIHCstainingofhumantonsil.SpeciesReactivityHumanAntibodyTypePolyclonalAntibodyEntrezGeneNumberNM_001504.1EntrezGeneSummaryCD183isaGprotein-coupledreceptorwithselectivityforthreechemokines,termedIP10(interferon-g-inducIBLe10kDaprotein),Mig(monokineinducedbyinterferon-g)andI-TAC(interferon-inducibleTcella-chemoattractant).IP10,MigandI-TACbelongtothestructuralsubfamilyofCXCchemokines,inwhichasingleaminoacidresidueseparatesthefirsttwooffourhighlyconservedCysresidues.Historically,CD183isthethirdCXCchemokinereceptordiscoveredand,therefore,commonlydesignatedasCXCR3.BindingofchemokinestoCD183inducescellularresponsesthatareinvolvedinleukocytetraffic,mostnotablyintegrinactivation,cytoskeletalchangesandchemotacticmigration.InhibitionbyBordetellapertussistoxinsuggeststhatheterotrimericGproteinoftheGi-subclasscoupletoCD183.Signaltransductionhasnotbeenfurtheranalyzedbutmayincludethesameenzymesthatwereidentifiedinthesignalingcascadeinducedbyotherchemokinereceptors.Asaconsequenceofchemokine-inducedcellulardesensitization(phosphorylation-dependentreceptorinternalization),cellularresponsesaretypicallyrapidandshortinduration.Cellularresponsivenessisrestoredafterdephosphorylationofintracellularreceptorsandsubsequentrecyclingtothecellsurface.AhallmarkofCD183isitsprominentexpressionininvitroculturedeffector/memoryTcells,andinTcellspresentinmanytypesofinflamedtissues.Inaddition,IP10,MigandI-TACarecommonlyproducedbylocalcellsininflammatorylesion,suggestingthatCD183anditschemokinesparticipateintherecruitmentofinflammatorycells.Therefore,CD183isatargetforthedevelopmentofsmallmolecularweightantagoNISTs,whichmaybeusedinthetreatmentofdiverseinflammatorydiseases.GeneSymbolCXCR3CD182CXC-R3IP10-RIP10Mig-RCD183CKR-L2CMKAR3GPR9CXCR-3MigRUniProtNumberP49682UniProtSummaryFUNCTION:SwissProt:P49682#ReceptorforCXCL9,CXCL10andCXCL11andmediatestheproliferationofhumanmesangialcells(HMC).Isoform2isareceptorforCXCL4andalsomediatestheinhibitoryactivitiesofCXCL9,CXCL10andCXCL11onthegrowthofhumanmicrovascularendothelialcells(HMVEC).Isoform2mayplayaroleinangiogenesis.Isoform3mediatesactivityofCXCL11.SIZE:368aminoacids;40660DaSUBCELLULARLOCATION:Cellmembrane;Multi-passmembraneprotein.TISSUESPECIFICITY:Isoform1andisoform2aremainlyexpressedinheart,kidney,liverandskeletalmuscle.Isoform1isalsoexpressedinplacenta.SIMILARITY:SwissProt:P49682##BelongstotheG-proteincoupledreceptor1family.PhysicochemicalInformationDimensionsMaterialsInformationMaterialsInformation
密理博(Millipore)公司成立于1954年,总部位于美国麻省,在全世界设有47个办事处,为100多个国家提供产品和技术服务。目前全球雇员超过5800人,在美国、法国和日本等国家拥有7家大型生产工厂,主要生产过滤膜及膜过滤产品。
20世纪80年代,密理博公司进入中国市场。先后在香港、北京、上海、广州及成都设立了办事机构,并于2000年4月在上海浦东外高桥保税区建立了密理博(上海)贸易有限公司。
为了更好地满足中国用户的需求,密理博中国主页于2006年11月向广大用户开放,介绍密理博中国有限公司的最新动态,力求为用户打造专业的产品与服务信息交流平台。
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