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Millipore/AB15452 | Anti-MAP2 Antibody/AB15452/500 µL
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DescriptionCatalogueNumberAB15452BrandFamilyChemicon®TradeNameChemiconDescriptionAnti-MAP2AntibodyAlternateNamesMicrotubuleassociatedprotein2ProductInformationFormatAffinityPurifiedPresentationAffinitypurifiedchickenimmunoglobulin.Twodifferentantibodieswerecombinedtomakethisproduct.LiquidinPBS,pH7.2with0.02%sodiumazide.StorageandShippingInformationStorageConditionsMaintainat2-8°Cinundilutedaliquotsforupto6monthsafterdateofreceipt.ApplicationsApplicationAnti-MAP2AntibodydetectslevelofMAP2&hasbeenpublished&validatedforuseinIC,IH.KeyApplicationsImmunocytochemistryImmunohistochemistryApplicationNotesImmunohistochemistry:1:1000-1:2,000using2%paraformaldehydefixedtissue.Immunocytochemistry:1:1000-1:2,000using2%paraformaldehydefixedcells.Optimalworkingdilutionsmustbedeterminedbyenduser.BIOLOGicalInformationImmunogenSyntheticpeptidescorrespondingtodifferentregionsofthehuman/mouseMAP2protein.HostChickenSpecificityMAP2[Microtubuleassociatedprotein2]SpeciesReactivityMouseSpeciesReactivityNoteOtherspecieshavenotyetbeentested.Itisexpectedthattheantibodywillalsoreactwithhumanduetoimmunogensequencesimilarity.AntibodyTypePolyclonalAntibodyEntrezGeneNumberNM_001039538.1NM_002374.3NM_031845.2NM_031847.2EntrezGeneSummaryThisgeneencodesaproteinthatbelongstothemicrotubule-associatedproteinfamily.Theproteinsofthisfamilyarethoughttobeinvolvedinmicrotubuleassembly,whichisanessentialstepinneurogenesis.Theproductsofsimilargenesinratandmouseareneuron-specificcytoskeletalproteinsthatareenrichedindentrites,implicatingaroleindeterminingandstABIlizingdentriticshapeduringneurondevelopment.Anumberofalternativelysplicedvariantsencodingdistinctisformshavebeendescribed.GeneSymbolMAP2MAP2BMAP-2MAP2CDKFZp686I2148MAP2APurificationMethodImmunoAffinityPurifiedUniProtNumberP11137UniProtSummaryFUNCTION:SwissProt:P11137#TheexactfunctionofMAP2isunknownbutMAPsmaystabilizethemicrotubulesagainstdepolymerization.Theyalsoseemtohaveastiffeningeffectonmicrotubules.SIZE:1827aminoacids;199539DaPTM:MAP2A/cisphosphorylated.PhosphorylateduponDNAdamage,probablybyATMorATR.SIMILARITY:SwissProt:P11137##Contains3Tau/MAPrepeats.PhysicochemicalInformationDimensionsMaterialsInformationMaterialsInformation

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