Pepinh-TRIFPepinh-TRIFUnit sizeCat. codeDocsPriceTRIF inhibitory peptide2 mg tlrl-pitrifTDSMSDS ￥8,103.00Please contact our distributorAdd to favoriteAboutSpecificationsContentsCitationsTRIF inhibitory peptidePepinh-TRIF is a 30 aa peptide that blocks TRIF signaling by interfering with TLR-TRIF interaction.PepinhTRIF contains the 14 aa that correspond to the sequence of the BB loop of TRIF (FCEEFQVPGRGELH) [1] linked to the cell-penetrating segment of the antennapedia homoedomain (RQIKIWFQNRRMKWKK) [2].Pepinh TRIF is provided with Pepinh-Control, a control peptide [1]. References:1. Toshchakov V. et al., 2005. Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction. J. Immunol., 175: 494 - 500.2. Derossi D. et al., 1994. The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem., 269: 10444-50.Back to the topSpecificationsWorking concentration: 5-50 μMPurity: ≥95% (UHPLC)Species reactivity: Human, mouseSequences:Pepinh-TRIF: RQIKIWFQNRRMKWKK-FCEEFQVPGRGELH-NH2(TRIF homodimerization sequence is underlined)Pepinh-Control: RQIKIWFQNRRMKWKK-SLHGRGDPMEAFII-NH2Molecular weights:Pepinh-TRIF: 3918Pepinh-Control: 3812Back to the topContentsPepinh-TRIF is provided as a white solid .2 mg of lyophilized Pepinh-TRIF2 mg of lyophilized Pepinh-Control2x1.5 ml endotoxin-free water Pepinh-TRIF is shipped at room temperature. Store at -20°C. Solid product is stable 1 year at -20°C.Upon resuspension, Pepinh-TRIF should be aliquoted and stored at -20°C.Avoid repeated freeze-thaw cycles.Resuspended product is stable for 6-8 months at -20°C when properly stored.Back to the topCitations2019 BJC DOI: 10.1038/s41416-019-0595-2Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages.Chen Q. et al.2018 J Immunol. 200(10):3599-3611.The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation.Ahmad R. et al.2012 J Neurosci. 32(22):7745-7757Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β mediates microglial phagocytosis of degenerating axons.Hosmane S, Tegenge MA, Rajbhandari L, Uapinyoying P, Kumar NG, Thakor N, Venkatesan A2011 PLoS ONE 6(9):e25504Leukocyte- and platelet-derived microvesicle interactions following in vitro and in vivo activation of toll-like receptor 4 by lipopolysaccharide.Xiong J, Miller VM, Hunter LW, Li Y, Jayachandran MLoad more
Invivogen公司的Plasmocin™属于新一代杀菌抗生素，能强烈的作用于感染支原体的细胞，杀灭支原体。同时，Plasmocin™能以一种较低的作用浓度发挥广谱的抗革兰氏阳性和革兰氏阴性的细菌作用，比如能作用于耐青霉素与链霉素的细菌，已经证实Plasmocin™对真核细胞没有毒性。
Plasmocin™包括两种新的杀菌成份，一种能作用于原核细胞的蛋白系统，另一种能干扰DNA的复制，因为Plasmocin™能以两种独立的特殊的方式作用靶原核细胞，可完全的去除支原体感染。和其他的抗支原体抗生素比较，Plasmocin™能同时作用于细胞内与细胞外的，因为Plasmocin™能有效地杀灭哺乳动物细胞感染的支原体，并不影响细胞本身的代谢，用Plasmocin™处理过的培养细胞，不会重新感染（从其他感染支原体细胞释放的）支原体。
支原体污染去除试剂：货号为ant-mpt：Plasmocin™ treatment，50 mg (2 x 1 ml），作用浓度为25μg/ml（1000x稀释）。
支原体预防试剂：货号为ant-mpp：Plasmocin™ prophylactic，25 mg (10 x 1 ml)，作用浓度为5μg/ml（500x稀释）。
产品信息如下：
品牌 | 货号 | 产品名称 | 规格 | 价格 |
InvivoGen | ant-mpt | Plasmocin™ treatment | 50 mg (2 x 1 ml） | 询价/现货 |
InvivoGen | ant-mpp | Plasmocin™ prophylactic | 25 mg (10 x 1 ml) | 询价/现货 |
其他相关产品还有：
1.Normocin™ 能预防支原体，细菌和真菌。
2.Fungin™ 预防和清除真菌。
3.Primocin™ 预防支原体，细菌和真菌：专为原代培养的细胞而设计。
4.Plasmocure™ 是Plasmocin的新一代产品，能在极少数支原体对Plasmocin耐受的情况下发挥作用。
产品信息如下：
品牌 | 货号 | 产品名称 | 规格 | 价格 |
InvivoGen | ant-nr-1 | Normocin™ | 500 mg (50 mg/ml) | 询价 |
InvivoGen | ant-fn-1 | Fungin™ | 75 mg (5 x 1.5 ml) | 询价 |
InvivoGen | ant-pm-1 | Primocin™ | 500 mg (10 x 1 ml) | 询价 |
InvivoGen | ant-pc | Plasmocure™ | 100 mg | 询价
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