Pepinh-MYDPepinh-MYDUnit sizeCat. codeDocsPriceMyD88 inhibitory peptide2 mg tlrl-pimydTDSMSDS ￥8,103.00Please contact our distributorAdd to favoriteAboutSpecificationsContentsCitationsMyD88 Inhibitory PeptidePepinh-MYD is a 26 aa peptide that blocks MyD88 signaling by inhibiting its homodimerization through binding.Pepinh-MYD contains a sequence from the MyD88 TIR homodimerization domain (RDVLPGT) [1] preceeded by a protein transduction sequence (RQIKIWFQNRRMKWKK) derived from antennapedia which enables the peptide to translocate through the cell membrane [2].Pepinh-MYD is provided with Pepinh-Control, a control peptide [3]. References:1. loiarro M. et al., 2005. Peptide-mediated Interference of TIR Domain Dimerization in MyD88 Inhibits Interleukin-1-dependent Activation of NF-{kappa}B. J. Biol. Chem., 280: 15809-14.2. Derossi D. et al., 1994. The third helix of the Antennapedia homeodomain translocates through biological membranes. J. Biol. Chem., 269: 10444-50.3. Toshchakov V. et al., 2005. Differential Involvement of BB Loops of Toll-IL-1 Resistance (TIR) Domain-Containing Adapter Proteins in TLR4- versus TLR2-Mediated Signal Transduction. J. Immunol., 175: 494 - 500.Back to the topSpecificationsWorking concentration: 5-50 μMPurity:  ≥95% (UHPLC)Species reactivity: Human, mouseSequences:Pepinh-MYD:    RQIKIWFQNRRMKWKK-RDVLPGTCVNS-NH2 (MyD88 homodimerization sequence is underlined)Pepinh-Control: RQIKIWFQNRRMKWKK-SLHGRGDPMEAFII-NH2Molecular weights:Pepinh-MYD: 3430Pepinh-Control: 3812Back to the topContentsPepinh-MYD is provided as a white solid.2 mg of lyophilized Pepinh-MYD2 mg of lyophilized Pepinh-Control2x1.5 ml endotoxin-free water Pepinh-MYD is shipped at room temperature. Store at -20°C. Solid product is stable 1 year at -20°C.Upon resuspension, Pepinh-MYD should be aliquoted and stored at -20°C.Avoid repeated freeze-thaw cycles.Resuspended product is stable for 6-8 months at -20°C when properly stored.Back to the topCitations2019 BJC DOI: 10.1038/s41416-019-0595-2Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages.Chen Q. et al.2018 Microb Pathog. DOI: 10.1016/j.micpath.2018.09.037Induction of TNF, CXCL8 and IL-1β in macrophages by Helicobacter pylori secreted protein HP1173 occurs via MAP-kinases, NF-κB and AP-1 signaling pathways.Tavares R. & Pathak SK.2017 Neoplasia. 19(3):175-184.] The Heparanase Inhibitor PG545 Attenuates Colon Cancer Initiation and Growth, Associating with Increased p21 Expression.Singh P. et al.2017 Biomaterials. 134:128-142.A macrophage-activating, injectable hydrogel to sequester endogenous growth factors for in situ angiogenesis.Feng Y. et al.2017 Cell Tissue Res. 369(3):541-554.CpG oligonucleotide-mediated co-stimulation of mouse invariant natural killer T cells negatively regulates their activation status.Kulkarni RR. et al.2017 Cardiovasc Res. 114(1):180-187.IL-1R and MyD88 signaling in CD4+ T cells promote Th17 immunity and atherosclerosis.Engelbertsen D. et al.2016 J Immunol. 196(5):2085-94LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.Llibre A. et al.2016 Mucosal Immunol. 10(4):924-935. MV140, a sublingual polyvalent bacterial preparation to treat recurrent urinary tract infections, licenses human dendritic cells for generating Th1, Th17, and IL-10 responses via Syk and MyD88.Benito-Villalvilla C. et al.2014 Diabetes. 63(11):3815-26Nucleotides released from palmitate challenged muscle cells through pannexin-3 attract monocytes.Pillon NJ, Li YE, Fink LN, Brozinick JT, Nikolayev A, Kuo MS, Bilan PJ, Klip A2013 J Biol Chem. 288(42):30544-57Endogenous interleukin-1β in neuropathic rats enhances glutamate release from the primary afferents in the spinal dorsal horn through coupling with presynaptic N-methyl-D-aspartic acid receptors.Yan X, Weng HR.2013 J Biol Chem. 288(15):10715-21Interferon-{gamma} and Granulocyte/Monocyte Colony-stimulating Factor Production by Natural Killer Cells Involves Different Signaling Pathways and the Adaptor Stimulator of Interferon Genes (STING)Souza-Fonseca-Guimaraes F, Parlato M, de Oliveira RB, Golenbock D, Fitzgerald K, Shalova IN, Biswas SK, Cavaillon JM, Adib-Conquy M.2012 J Neurosci. 32(22):7745-7757Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β mediates microglial phagocytosis of degenerating axons.Hosmane S, Tegenge MA, Rajbhandari L, Uapinyoying P, Kumar NG, Thakor N, Venkatesan ALoad more