OVERVIEW: Synonyms Monoclonal EBV Latent Membrane Protein antibody, Anti-EBV Latent Membrane Protein antibody, EBV antibody, Epstein-Barr Virus Latent Membrane Protein antibody Specificity EBV Cross Reactivity To be determined by end-user Applications IHC Immunogen EBV latent membrane protein antibody was raised in mouse using recombinant fusion protein containing sequences of bacterial beta-galactosidase and the EBV encoded LMP-1 as the immunogen. SPECIFICATIONS: Host Mouse Clone CS1-4 Isotype IgG1 Form & Buffer Lyophilized tissue culture supernatant containing 15mM NaN3. Reconstitute with 1 ml of sterile distilled water. STORAGE & SAFETY: Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Usage Assay Information: Usage Recommendations IHC: 1:100-1:200 GENERAL INFORMATION: Biological Significance Epstein-Barr virus (EBV) is one of the eight known human herpes viruses and belongs to the Gammaherpes viriniae, the same subfamily as human herpesvirus type 8 (HHV-8). Herpes viruses have large double strand DNA genomes and are complex viruses often encoding over 35 proteins including enzymes involved in nucleic acid metabolism, DNA synthesis and protein processing in addition to viral structural proteins. These viruses are capable of entering a latent phase where the host shows no visible signs of infection and levels of infectious agent become very low. During latency, viral gene expression is restricted to only a few genes. Latent membrane protein (LMP-1) is a 60 kDa protein encoded by the BNLF1 gene of EBV.