OVERVIEW: Synonyms Monoclonal MUC1 antibody, Anti-MUC1 antibody, MU 1c antibody, MU 1c, Mucin-1 antibody, MUC1, MU-1c, MU 1c antibody, MU-1c antibody, MU-1c antibody Specificity Human Cross Reactivity To be determined by end-user Applications IHC-P Immunogen MUC1 antibody was raised in mouse using human breast cancer cell line ZR75-1 as the immunogen. SPECIFICATIONS: Host Mouse Clone MA552 Isotype IgG1 Form & Buffer Lyophilized from PBS, pH7.6, with 1% BSA and 15mM NaN3. Reconstitute with 1 ml of distilled water. STORAGE & SAFETY: Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Usage Assay Information: Usage Recommendations IHC-P:1:100 GENERAL INFORMATION: Biological Significance Mucins are heavily glycosylated proteins which constitute the major components of mucus covering the surface of epithelial tissues. Nine distinct epithelial mucin genes (Muc-1, 2, 3, 4, 5AC, 5B, 6, 7 and 8) have been identified. Various immunohistochemical and in situ hybridization studies have reported that these mucins are differentially expressed in epithelia with cell-type specificity. In gastric cancer, alterations in mucin polypeptide expression have been reported, including the loss of expression of Muc-5AC glycoprotein, increased mucin heterogeneity, glycosylation changes and the expression of simple mucin-type carbohydrates.