产品说明
Rabbit anti Human Sphingomyelin Phosphodiesterase 3Catalogue number: X2360PProduct Type Polyclonal AntibodyUnits100 µg HostRabbit Species reactivity HumanApplication Western BlotWestern Blotting BackgroundSphingomyelin phosphodiesterase 3 catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine.Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these two cellular events independently. It also hydrolyzes sphingosylphosphocholine. Sphingomyelin phosphodiesterase 3 regulates the cell cycle by acting as a growth suppressor in confluent cells. It likely acts as a regulator of postnatal development and participates in bone and dentin mineralization.It is activated by unsaturated fatty acids and phosphatidylserine.it is predominantly expressed in the brain.Synonyms: nSMase2; Neutral sphingomyelinase 2; EC 3.1.4.12 Source Immunogen: Synthetic peptide derived from human sphingomyelin phosphodiesterase 3 Product Product Form: Unconjugated Formulation: Provided as solution in phosphate buffered saline with 0.08% sodium azide Purification Method: Ammonium Sulfate PrecipitationConcentration: See vial for concentration ApplicationsAntibody can be used for Western blotting (1-5 µg/ml starting dilution).Optimal concentration should be evaluated by serial dilutions.Functional Analysis: Western BlottingPositive Control: Predominantly expressed in the brain. StorageProduct should be stored at -20ºC. Aliquot to avoid freeze/thaw cycles Product Stability: Products are stable for one year from purchase when stored properly Shipping Conditions: Ship at ambient temperature, freeze upon arrival CautionThis product is intended FOR RESEARCH USE ONLY, and FOR TESTS IN VITRO, not for use in diagnostic or therapeutic procedures involving humans or animals. It may contain hazardous ingredients. Please refer to the Safety Data Sheets (SDS) for additional information and proper handling procedures. Dispose product remainders according to local regulations.This datasheet is as accurate as reasonably achievable, but Exalpha Biologicals accepts no liability for any inaccuracies or omissions in this information. References1. Hofmann, K., et al. Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase.; Proc. Natl. Acad. Sci. U.S.A. 97:5895-5900(2000).2. Miura, Y., et al. Hydrolysis of sphingosylphosphocholine by neutral sphingomyelinases.; FEBS Lett. 557:288-292(2004).3. Marchesini, N., et al. Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells.; J. Biol. Chem. 279:25101-25111(2004).Protein Reference(s)Database Name: UniProt Accession number: Q53YV1 (Human) Species Accession: Human Safety Datasheet(s) for this product:EA_Sodium Azide/wp-content/uploads/SDS/Antibody SDS with Sodium AzideV2.pdf
xalpha有限公司于2000年在马萨诸塞州雪莉(美国)成立。该公司主要通过开发和生产一流的抗体来支持生命科学领域的研究人员和科学家。其领域涉及信号通路、凋亡、增殖、炎症、免疫学、传染病学和细胞间结构研究等方面。Exalpha主要产品线包括Proliferation&apoptosis, Enzymes&Proteins, Clinical IHC Markers , GPCRs等多个产品线,可提供给全球的科研实验室,制药企业,生物技术和诊断公司,医院等,目前旗下的代理公司遍布全球。
新品排行榜
1
Exalpha/Goat anti Monkey IgG (he...
2
Exalpha/Goat anti Monkey IgG (Fc...
3
Exalpha/Goat anti Monkey IgG (Fc...
4
Exalpha/Mouse anti CD11a (activi...
5
Exalpha/Mouse anti Human IgG3 (G...
6
Exalpha/Mouse anti Human secreto...
7
Exalpha/Mouse anti CD3/GM-4011/....
8
Exalpha/Goat anti Monkey IgG (Fc...
9
Exalpha/Goat anti Monkey IgG (Fc...
10
Exalpha/Streptavidin, conjugated...
文章排行榜
1
杭州奥盛MK200-4干式恒温器(加热高温型)恒温金属浴/标配4个模块定制...
2
绵羊抗小鼠 Bax-beta - Exalpha Biologicals inc.
3
FIX&PERM® 套件 1000 - Exalpha Biologicals inc.
4
小鼠抗双链 RNA (J2) - Exalpha Biologicals inc.
5
双链 RNA (dsRNA) ELISA 试剂盒(基于 K1)- Exalpha Biologicals inc.
6
人 IgG1 λ G1m (a) - Exalpha Biologicals inc.
7
CD274、PD-L1 - Exalpha Biologicals Inc.
8
I 型胶原蛋白,鲑鱼 - Exalpha Biologicals inc.
9
小鼠抗双链 RNA (J5) - Exalpha Biologicals inc.
10
正常鹌鹑 IgY(源自蛋),与 FITC 偶联 - Exalpha Biologicals inc.
微信公众号
手机扫码,关注动态