首页 > Exalpha > Exalpha/Goat anti Human kininogen/GAHu-Kg/1 ml

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Exalpha/Goat anti Human kininogen/GAHu-Kg/1 ml

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GAHu-Kg-1ml

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Exalpha

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ProductCodeProductNameGoatantiHumankininogenSize1mlPrice(USD)$362BackgroundTheheavychainsinHMWKandLMWKshareimmunologicdeterminants,buttheyhavenoprocoagulantactivities.ThelightchainofHMWKisuniquetothismoleculeandcarriestheentireprocoagulantactivityofthemolecule.Theantiserumdoesnotdistinctbetweendifferentformsofkininogen.Thepresenceofnon-precipitatingantibodieshasnotbeenassayed.Iftheantiserumistobeusedinnon-precipitatingantibody-bindingassays(immunocytochemical,immunohistochemical,solidphaseproceduressuchasELISA)propercontrolsshouldbeincluded.NoreactionisobtainedwithanyotherplasmaproteincomponentorserumInprecipitatingtechniquesasimmunoelectrophoresisandsingleordoublerADIalimmunodiffusionandelectroimmunodiffusion(Laurell),toidentifythepresenceofkininogeninhumanplasmaorotherbodyfluidsortodetermineitsconcentration.Forelectroimmunodiffusionaconcentrationof1-2%ofantiseruminthegelisrecommended.HostGoatSpeciesReactivityHumanProductUsagePrecipitatingpolyclonalGoatantiSerumtoHumankininogenProductTypePrimaryAntibodiesApplicationsImmunoprecipitationFieldsofInterestCardiovascularProductSourceHumanplasmacontainsatleasttwodistinctformsofkininogen,thecarriermoleculeofbradykinin,whichcanbedistinguishedbytheirphysical,chemicalandimmunochemicalproperties.Theyaredesignatedhigh-molecular-weightkininogen(HMWK)andlow-molecularweightkininogen(LMWK).HMWK(MW110,000)andLMWK(MW50,000)bothliberatebradykininfollowingtheactionofkallikrein.HMWKcirculatesasanon-enzymaticfactorthatiscentraltocontactactivationreactions.LMWKplaysnoknownroleintheactivationofcoagulation.Normaladultplasmalevelsare7mg/100mlforHMWKasdeterminedbyelectroimmunodiffusionand9mg/100mlbasedonhaemagglutinationinhibitionassaysandRIA.Lowplasmakininogenlevelsareseeninnewbornandpre-terminfants.HMWKisabsentincongenitalkininogendeficiencyofthenamedaffectedfamiliesFitzgeraldandReid;WilliamsandFlaujeaclackbothHMWKandLMWK.Theconditionisassociatedwiththedecreasedfibrinolyticactivityandkininformationbutisasymptomatic.Purifiedkininogenfrompooledhumanplasmaisusedfortheimmunization.FreundProductFormulationDelipidated,heatinactivated,lyophilized,stablewholeantiserumNopreservativeadded.TotalproteinandIgGconcentrationsintheantiserumarecomparabletothoseofpoolednormalgoatserum.Noforeignproteinsadded.ProductSpecificityTheantiSerumdoesnotcrossreactwithanyothercomponentofHumanplasma.Inter-speciescrossreactivityisanormalfeatureofantibodiestoplasmaproteinssincetheyfrequentlyshareantigenicdeterminants.Cross-reactivityofthisantiSerumhasnotbeentestedindetail.StorageConditionsThelyophilizedantiserumisshippedatambienttemperatureandmaybestoredat+4

xalpha有限公司于2000年在马萨诸塞州雪莉（美国）成立。该公司主要通过开发和生产一流的抗体来支持生命科学领域的研究人员和科学家。其领域涉及信号通路、凋亡、增殖、炎症、免疫学、传染病学和细胞间结构研究等方面。Exalpha主要产品线包括Proliferation&apoptosis, Enzymes&Proteins, Clinical IHC Markers , GPCRs等多个产品线，可提供给全球的科研实验室，制药企业，生物技术和诊断公司，医院等，目前旗下的代理公司遍布全球。