产品说明
SpecificationsSPECIES:HumanSOURCESPECIES:HumanCellsSEQUENCE:Leu24-Gln186FUSIONTAG:C-6HistagTESTEDAPPLICATIONS:APPLICATIONS:ThisrecombinantproteincanbeusedforBIOLOGicalassays.Forresearchuseonly.PropertiesPURITY:Greaterthan95%asdeterminedbyreducingSDS-PAGE.Endotoxinlevellessthan0.1ng/ug(1IEU/ug)asdeterminedbyLALtest.PREDICTEDMOLECULARWEIGHT:18.1kDPHYSICALSTATE:LyophilizedBUFFER:Lyophilizedfroma0.2umfilteredsolutionofPBS,pH7.4.Itisnotrecommendedtoreconstitutetoaconcentrationlessthan100ug/ml.DissolvethelyophilizedproteininddH2O.STORAGECONDITIONS:Lyophilizedproteinshouldbestoredat-20˚C,thoughstableatroomtemperaturefor3weeks.Reconstitutedproteinsolutioncanbestoredat4-7˚Cfor2-7days.Aliquotsofreconstitutedsamplesarestableat-20˚Cfor3months.AdditionalInfoALTERNATENAMES:CD137,ILA,TNFRSF9,4-1BBligandreceptor,CDw137,T-cellantigen4-1BBhomolog,T-cellantigenILAACCESSIONNO.:Q07011PROTEINGINO.:767904139BackgroundTumornecrosisfactorreceptorsuperfamilymember9(TNFRSF9),alsoknownasCD137and4-1BB,isaninducIBLeTcellsurfaceproteinbelongingtothetumornecrosisfactorreceptorsuperfamily.Itisasingle-passtypeImembraneproteinwhichcontains4TNFR-Cysrepeats.Thehumanandmouseproteinsshare60%aminoacidsequenceidentity.CD137isexpressedbymesenchymalcells,includingendothelialcells,chondrocytes,andcellsofthecentralnervoussystem.CD137isalsobroadlyexpressedbycellsofthehumanimmunesystem,isbroadlyexpressedbycellsofthehumanimmunesystem,includingactivatedCD8+andCD4+Tcells,activatednaturalkiller(NK)cells,folliculardendriticcells(FDCs)andmonocytes.CD137hasdiverserolesintheimmuneresponse,theonekeyfunctionistopromotethesurvivalofbothTcellsanddendriticcellsbybindingthecognateligandCD137L(4-1BBL).
ProSci
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