产品说明
SpecificationsSPECIES:HumanSOURCESPECIES:E.coliSEQUENCE:GLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGCSTESTEDAPPLICATIONS:BIOLOGICALACTIVITY:TheED50wasdeterminedbyitsABIlitytoinhibittheproliferationofmurineMPC-11cellsis≤2.0ng/mL,correspondingtoaspecificactivityof≥5x105units/mg.PropertiesPURITY:Greaterthan97%bySDS-PAGEgelandHPLCanalyses.Endotoxinlevelislessthan0.1ngperμg(1EU/μg).PHYSICALSTATE:LyophilizedSTORAGECONDITIONS:ThelyophilizedActivinArecombinantproteinisstableforatleast2yearsfromdateofreceiptat-20˚C.ReconstitutedActivinAisstableforatleast3monthswhenstoredinworkingaliquotswithacarrierproteinat-20˚C.Aswithanyprotein,exposingActivinArecombinantproteintorepeatedfreeze/thawcyclesisnotrecommended.Whenworkingwithproteinscareshouldbetakentokeeprecombinantproteinatacoolandstabletemperature.AdditionalInfoALTERNATENAMES:JV18,MADH2,MADR2,JV18-1,hMAD-2,hSMAD2,Mothersagainstdecapentaplegichomolog2,MADhomolog2ACCESSIONNO.:NP_001003652.1PROTEINGINO.:51173730BackgroundActivinAisaTGF-βfamilymemberthatexhibitsawiderangeofbiologicalactivitiesincludingregulationofcellularproliferationanddifferentiation,andpromotionofneuronalsurvival.ElevatedlevelsofActivinAinhumancolorectaltumorsandinpostmenopausalwomenhavebeenimplicatedincolorectalandbreastcancers,respectively.ThebiologicalactivitiesofActivinAcanbeneutralizedbyinhibinsandbythediffusIBLeTGF-βantagoNIST,follistatin.HumanActivinAisa26.0kDadisulfide-linkedhomodimeroftwoβAchains,eachcontaining116aminoacidresidues.
ProSci
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